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1. www.ncbi.nlm.nih.gov › pmc › articlesMolecular Mechanisms of Antiviral Agents against Dengue Virus

   www.ncbi.nlm.nih.gov › pmc › articles

   Mar 8, 2023 · When the concentration was increased to 20 μM, a greater reduction in the production of DENV-2 virions (69–79%) was observed at 4 h post-infection. Peptide 3 was the most effective in lowering the production of DENV-2 virions, but it also caused the highest amount of cell death when administered at 20 μM.

   • Current Status of Dengue Therapeutics Research and ...

     This review will provide a brief account of the status of...

   • Dengue structural proteins as antiviral drug targets: Current ...

     Dengue virus belongs to the class of RNA viruses and...

2. ncbi.nlm.nih.gov › pmc › articlesDengue: Update on Clinically Relevant Therapeutic Strategies ...

   ncbi.nlm.nih.gov › pmc › articles

   Apr 18, 2023 · Dengue risk factors. Secondary heterologous dengue infection is the most well-established risk factor for severe dengue. This is thought to be attributable to antibody-dependent enhancement of infection (ADE), which occurs when viruses bound to sub-neutralizing antibodies are opsonized by immune cells like dendritic cells, monocytes/macrophages through Fc receptor, which then results in ...

   • DOI: 10.1007/s40506-023-00263-w

   • Published: 2023

3. People also ask

   Which drugs are used in clinical trials for dengue?

   • The most recent proof-of-concept clinical trials for dengue have been performed using repurposed or off-patent drugs, namely chloroquine, prednisolone, balapiravir, celgosivir, and lovastatin (Table 1 ). These trials have all used the conventional double-blinded, randomized, placebo-controlled design with clearly defined primary end points.

   Current Status of Dengue Therapeutics Research and Development

   www.ncbi.nlm.nih.gov/pmc/articles/PMC5388029/

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   What are antiviral drug targets for dengue?

   • Antiviral drug targets for dengue The viral components of dengue can be targeted effectively to develop antiviral drugs classified as viral protein targets and viral enzyme targets. Viral protein targets can be sub-classified into structural and non-structural protein targets.

   Dengue structural proteins as antiviral drug targets: Current status in

   www.sciencedirect.com/science/article/pii/S0223523421003767

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   Can synergistic drug combinations be used for the treatment of dengue?

   • The combinations of antivirals with different mechanisms of action could be evaluated to develop synergistic drug combinations for the treatment of dengue at any stage of the infection.

   Molecular Mechanisms of Antiviral Agents against Dengue Virus

   www.ncbi.nlm.nih.gov/pmc/articles/PMC10056858/

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4. www.sciencedirect.com › science › articleDengue structural proteins as antiviral drug targets: Current ...

   www.sciencedirect.com › science › article

   Oct 5, 2021 · Dengue virus is a positive-sense single-stranded RNA virus belonging to the family Flaviviridae, genus Flavivirus [1, 2]. Based on the difference in the surface structures, the dengue virus has four serotypes (DENV1-4), and the fifth serotype was discovered in 2013 [[3], [4], [5]]. Even though dengue is an age-old infectious disease, its spread ...

   • Author: Akshatha H. S, Gurubasavaraj V. Pujar, Arun Kumar Sethu, Meduri Bhagyalalitha, Manisha Singh

   • Publish Year: 2021

5. www.nature.com › articles › d41586/021/02638-9A step towards therapeutics for dengue - Nature

   www.nature.com › articles › d41586/021/02638-9

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   Oct 6, 2021 · An effective drug against dengue virus (DENV) is urgently needed, because this mosquito-transmitted virus represents a tremendous public-health burden, with about 3.9 billion people at risk of ...

6. www.nejm.org › doi › fullDengue | New England Journal of Medicine

   www.nejm.org › doi › full

   Apr 12, 2012 · VOL. 366 NO. 15. Dengue is a self-limited, systemic viral infection transmitted between humans by mosquitoes. The rapidly expanding global footprint of dengue is a public health challenge with an ...