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1. en.wikipedia.org › wiki › CYP2D6CYP2D6 - Wikipedia

   en.wikipedia.org › wiki › CYP2D6

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   Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene. CYP2D6 is primarily expressed in the liver. It is also highly expressed in areas of the central nervous system, including the substantia nigra.

   • Aliases: CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1, cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 2D6

2. www.ncbi.nlm.nih.gov › pmc › articlesA Review of the Important Role of CYP2D6 in Pharmacogenomics

   www.ncbi.nlm.nih.gov › pmc › articles

   Oct 30, 2020 · CYP2D6 overlaps with four distinct therapeutic areas. BCHE: Butyrylcholinesterase. CFTR: Cystic fibrosis transmembrane conductance regulator. CYP2B6, CYP2C9, CYP2C19, CYP3A5, CYP4F2: Members of cytochrome P450 superfamily. DPYD: Dihydropyrimidine dehydrogenase. F5: Factor 5. G6PD: Glucose-6-phosphate dehydrogenase. IFNL3: Interferon lambda 3.

   • Author: Christopher Taylor, Ian Crosby, Vincent Yip, Peter Maguire, Munir Pirmohamed, Richard M. Turner

   • Publish Year: 2020

3. www.ncbi.nlm.nih.gov › pmc › articlesA Scoping Review of the Evidence Behind CYP2D6 Inhibitor ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) contributes to 2% and 0.7% of the overall hepatic and intestinal cytochrome P450 enzyme, respectively, ( 1) and is estimated to be responsible for metabolism of 25% of commonly prescribed drugs (e.g., antidepressants, antipsychotics, opioids, beta blockers).

   • Author: Emily J. Cicali, D. Max Smith, Benjamin Q. Duong, Lukas G. Kovar, Larisa H. Cavallari, Julie A. John...
   • DOI: 10.1002/cpt.1768

   • Publish Year: 2020
   • Published: 2020/07

4. www.sciencedirect.com › cyp2d6CYP2D6 - an overview | ScienceDirect Topics

   www.sciencedirect.com › cyp2d6

   CYP2D6 is one of the most polymorphic CYP genes in humans among the CYPs, accounting for around 80 different allelic variants and 130 genetic variations described [50].

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6. www.ncbi.nlm.nih.gov › pmc › articlesCYP2D6: novel genomic structures and alleles - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   CYP2D6 is a polymorphic gene. It has been observed to be deleted, to be duplicated and to undergo recombination events involving the CYP2D7 pseudogene and surrounding sequences. The objective of this study was to discover the genomic structure of CYP2D6 recombinants that interfere with clinical genotyping platforms that are available today. Methods

   • Author: Whitney E. Kramer, Denise L. Walker, Dennis J. O’Kane, David A. Mrazek, Pamela K. Fisher, Brian A. D...
   • DOI: 10.1097/FPC.0b013e3283317b95

   • Publish Year: 2009
   • Published: 2009/10

7. www.nature.com › articles › s41397/020/00205-5Cyrius: accurate CYP2D6 genotyping using whole-genome ...

   www.nature.com › articles › s41397/020/00205-5

   Jan 18, 2021 · Cytochrome P450 2D6 ( CYP2D6) encodes one of the most important drug-metabolizing enzymes and is responsible for the metabolism of about 21% of clinically used drugs [ 2 ]. The CYP2D6 gene is...

8. People also ask

   What does CYP2D6 stand for?

   • Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) contributes to 2% and 0.7% of the overall hepatic and intestinal cytochrome P450 enzyme, respectively, ( 1) and is estimated to be responsible for metabolism of 25% of commonly prescribed drugs (e.g., antidepressants, antipsychotics, opioids, beta blockers).

   A Scoping Review of the Evidence Behind CYP2D6 Inhibitor

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7292748/

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   Where is CYP2D6 expressed?

   • CYP2D6 is primarily expressed in the liver. It is also highly expressed in areas of the central nervous system, including the substantia nigra . CYP2D6, a member of the cytochrome P450 mixed-function oxidase system, is one of the most important enzymes involved in the metabolism of xenobiotics in the body.

   CYP2D6 - Wikipedia

   en.wikipedia.org/wiki/CYP2D6

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   Why is CYP2D6 important?

   • CYP2D6 is a particularly important and well-studied member of the CYP superfamily. In the late 1970s, the metabolism of debrisoquine, and separately sparteine, were both shown to be highly variable yet controlled by a single autosomal gene, which we now know to by CYP2D6 [ 28, 29 ].

   A Review of the Important Role of CYP2D6 in Pharmacogenomics

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7692531/

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   What is the CYP2D6 gene?

   • The human CYP2D6 gene is relatively short, spanning just ~4.3 Kbps on the long arm of chromosome 22 (22q13.2), is encoded by nine exons, is translated into CYP2D6 protein that localises to the endoplasmic reticulum, and is highly expressed in liver, brain, intestinal tissue and lymphoid cells [ 10, 30 ].

   A Review of the Important Role of CYP2D6 in Pharmacogenomics

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7692531/

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9. www.nature.com › articles › gim201680Prediction of CYP2D6 phenotype from genotype across world ...

   www.nature.com › articles › gim201680

   Jul 7, 2016 · Owing to its highly polymorphic nature and major contribution to the metabolism and bioactivation of numerous clinically used drugs, CYP2D6 is one of the most extensively studied...