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  1. Greenville County is the most populous county in Upstate South Carolina as well as the state. It is the central county of the Greenville-Anderson-Greer, SC Metropolitan Statistical Area, which in turn is part of the Greenville-Spartanburg-Anderson, SC Combined Statistical Area.

  2. Greenville County ( / ˈɡriːnvɪl / GREEN-vil; locally / ˈɡriːnvəl / GREEN-vəl) is located in the U.S. state of South Carolina. As of the 2020 census, the population was 525,534, making it the most populous county in the state. Its county seat is Greenville.

  3. Greenville is the primary city of "the Upstate" of South Carolina, an area that includes the six counties of northwestern South Carolina along the borders of North Carolina and Georgia.

  4. May 17, 2016 · The fourth largest city in South Carolina, Greenville traces its origins to 1797 when Lemuel Alston, the largest landowner in Greenville County, laid out the “Greenville C. H. Village of Pleasantburg” on either side of Pearis’s wagon road on the east bank of the Reedy River. 5 minutes to read. (Greenville County; 2020 pop. 72,227).

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