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1. • Strong similarities

     • Overall, canine mammary tumors showed strong similarities to human breast cancer in terms of clinical and molecular aspects; therefore, they could be suggested as a model for human breast cancer in comparative oncology.
     Reference:

     Canine Mammary Tumors as a Potential Model for Human Breast ...

2. www.ncbi.nlm.nih.gov › pmc › articlesCanine Mammary Tumors as a Potential Model for Human Breast...

   www.ncbi.nlm.nih.gov › pmc › articles

   May 10, 2024 · Overall, canine mammary tumors showed strong similarities to human breast cancer in terms of clinical and molecular aspects; therefore, they could be suggested as a model for human breast cancer in comparative oncology.

   • DOI: 10.1155/2024/9319651
   • Published: 2024

   • Publication: Vet Med Int. 2024; 2024: 9319651.

3. People also ask

   What are the similarities between canine and human breast cancer?

   • Comparative gene expression profiling and whole-exome sequencing studies between canine and human breast cancers revealed similarities such as cell cycle activation, WNT–β-Catenin signaling, PI3K–AKT and ERK signaling and mutations in ESR1 and BRCA2 30.

   Comparative oncology: overcoming human cancer through companion animal

   www.nature.com/articles/s12276-023-00977-3

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   What are the clinical similarities between human and canine mammary tumors?

   • In addition to the spontaneous tumor presentation, the clinical similarities between human and canine mammary tumors (CMT) include the age at onset, hormonal etiology and course of the diseases. Furthermore, factors that affect the disease outcome, including tumor size, stage and lymph node invasion, are similar in HBC and CMT.

   Canine mammary tumors as a model for human disease - PMC

   www.ncbi.nlm.nih.gov/pmc/articles/PMC6004712/

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   Can a dog be a model for human breast cancer?

   • [ PubMed] [ CrossRef] [ Google Scholar] Animal models for examining human breast cancer (HBC) carcinogenesis have been extensively studied and proposed. With the recent advent of immunotherapy, significant attention has been focused on the dog as a model for human cancer. Dogs develop mammary ...

   Canine mammary tumors as a model for human disease - PMC

   www.ncbi.nlm.nih.gov/pmc/articles/PMC6004712/

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4. www.nature.com › articles › s12276/023/00977-3Comparative oncology: overcoming human cancer through ...

   www.nature.com › articles › s12276/023/00977-3

   Apr 3, 2023 · 17 Citations. 30 Altmetric. Metrics. Abstract. Comparative oncology is a field of study that has been recently adopted for studying cancer and developing cancer therapies. Companion animals...

5. www.ncbi.nlm.nih.gov › pmc › articlesCanine mammary tumors as a model for human disease

   www.ncbi.nlm.nih.gov › pmc › articles

   Apr 2, 2018 · With the recent advent of immunotherapy, significant attention has been focused on the dog as a model for human cancer. Dogs develop mammary tumors and other cancer types spontaneously with an intact immune system, which exhibit a number of clinical and molecular similarities to HBC.

   • Author: Somaia M. Abdelmegeed, Sulma Mohammed
   • DOI: 10.3892/ol.2018.8411

   • Publish Year: 2018
   • Publication: Oncol Lett. 2018 Jun; 15(6): 8195-8205.

6. www.ncbi.nlm.nih.gov › pmc › articlesCurrent biomarkers of canine mammary tumors - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Oct 29, 2018 · Mammary tumors are the second most common neoplasia in dogs. Due to the high similarity of canine mammary tumors (CMT) to human breast cancers (HBC), human biomarkers of HBC are also detectable in cases of CMT. The evaluation of biomarkers enables clinical diagnoses, treatment options and prognosis for bitches suffering from this disease.

   • Author: Ilona Kaszak, Anna Ruszczak, Szymon Kanafa, Kamil Kacprzak, Magdalena Król, Piotr Jurka

   • Publish Year: 2018

7. www.nature.com › articles › s41598/022/21706-2A living biobank of canine mammary tumor organoids as a ...

   www.nature.com › articles › s41598/022/21706-2

   Oct 27, 2022 · Mammary tumors in dogs hold great potential as naturally occurring breast cancer models in translational oncology, as they share the same environmental risk factors, key histological features ...

8. www.sciencedirect.com › science › articleProfiling canine mammary tumors: A potential model for ...

   www.sciencedirect.com › science › article

   Feb 1, 2024 · Canine mammary tumors (CMTs) are a potential model for human breast cancer (HBC). •. CMTs and HBC share some similar important molecular features. •. Molecular profiling of CMTs supports their use as a study model for HBC. •. There are several limitations associated with CMTs that need to be considered. Abstract.

9. link.springer.com › chapter › 10Comparing Human Breast Cancer with Canine Mammary Cancer

   link.springer.com › chapter › 10

   • Cached

   Jan 31, 2017 · Human breast cancer (HBC) is a neoplastic disease of the epithelium of mammary glands that occurs mostly, though not only, in females. In this chapter, we will describe and compare the development, clinical symptoms, and treatment of breast cancer and mammary carcinoma in humans and dogs, respectively.