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The mammalian target of rapamycin (mTOR), [5] also referred to as the mechanistic target of rapamycin, and sometimes called FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene.
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They function by inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases (PIKKs). mTOR regulates cellular metabolism, growth, and proliferation by forming and ...
mTORC1, also known as mammalian target of rapamycin complex 1 or mechanistic target of rapamycin complex 1, is a protein complex that functions as a nutrient/energy/redox sensor and controls protein synthesis.
Jun 6, 2016 · Since the discovery that rapamycin, a small molecule inhibitor of the protein kinase mTOR (mechanistic Target Of Rapamycin), can extend the lifespan of model organisms including mice, interest in understanding the physiological role and molecular targets of this pathway has surged.
- Brian K. Kennedy, Dudley W. Lamming
- 10.1016/j.cmet.2016.05.009
- 2016
- 2016/06/06
Oct 3, 2023 · The mechanistic target of rapamycin (mTOR) signaling pathway associated with RA connects immune and metabolic signals, which regulates immune cell proliferation and differentiation, macrophage polarization and migration, antigen presentation, and synovial cell activation.
- Fen Zhang, Ting Cheng, Sheng-Xiao Zhang
- Arthritis Res Ther. 2023; 25: 187.
- 10.1186/s13075-023-03181-w
- 2023
May 4, 2023 · Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity in diverse model...
Jun 14, 2016 · The mechanistic (previously referred to as mammalian) target of rapamycin (mTOR) is a serine/threonine protein kinase that is inhibited by rapamycin, a compound produced by bacteria originally isolated from the soil of Easter Island that inhibits the proliferation of eukaryotic cells (Vézina et al., 1975).
