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Many experts advocate that women with von Willebrand disease may have a vaginal delivery safely, with cesarean delivery reserved for standard indications 7 10. Because von Willebrand disease can be transmitted as an autosomal dominant or recessive trait, the fetus can have up to a 50% risk of being affected.
A standard definition of post-partum hemorrhage (PPH) considers the threshold of >500 mL blood loss for vaginal delivery and of >1,000 mL for caesarean section 13. Rates of PPH in Western Countries based on hospital discharge may range from 3 to 6%, while cases needing blood transfusion are as low as 1 % 10.
- Giancarlo Castaman, Paula D. James
- 10.1111/ejh.13250
- 2019
- 2019/08
May 20, 2019 · 1 INTRODUCTION. Von Willebrand disease (VWD), the most frequent autosomal inherited bleeding disorder, is caused by quantitative or qualitative defects of von Willebrand factor (VWF), an adhesive protein that binds platelets to exposed sub-endothelium and carries factor VIII (FVIII) in circulation. 1, 2 As a consequence, in addition to the defect of VWF, also FVIII, the protein deficient in ...
- Giancarlo Castaman, Paula D. James
- 2019
With proper care, women with von Willebrand disease (VWD) can have a successful pregnancy and deliver a healthy child. A woman who has VWD should be monitored closely throughout her pregnancy by her doctors. It is important for a woman’s health care providers to be aware that she has VWD so that plans can be made for a safe delivery.
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Can a woman with von Willebrand disease have a successful pregnancy?
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Does von Willebrand disease cause postpartum hemorrhage?
Nov 30, 2009 · Introduction. Pregnancy and delivery are considered situations predisposing to a high risk of bleeding in women with von Willebrand’s disease (VWD). 1, 2 While patients with mild deficiency usually show a spontaneous complete correction of basal low factor VIII (FVIII) and von Willebrand factor (VWF) levels during pregnancy, patients with dysfunctional (type 2) or severe (type 3) VWD usually ...
- Giancarlo Castaman, Alberto Tosetto, Francesco Rodeghiero
- 10.3324/haematol.2009.011239
- 2010
- Haematologica. 2010 Jun; 95(6): 963-969.
Jun 7, 2022 · Von Willebrand disease (VWD), first described by Dr. Erik von Willebrand, is the most common autosomal inherited bleeding disorder. It is caused by deficiency or dysfunction of von Willebrand factor (VWF), a plasma protein that mediates the initial adhesion of platelets at sites of vascular injury, and binds and stabilizes blood clotting factor ...
Jan 10, 2022 · Von Willebrand disease (VWD) is a common bleeding disorder that typically manifests with mucosal bleeding. 1 Although women and men are equally likely to be affected, women with VWD are more likely to have bleeding symptoms related to the high prevalence of heavy menstrual bleeding (HMB).
