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The method by which doctors gather information about a patient's past and present medical condition in order to make informed clinical decisions is called the history and physical (a.k.a. the H&P).
A clinical trial produces data that could reveal quantitative differences between two or more interventions; statistical analyses are used to determine whether such differences are true, result from chance, or are the same as no treatment (placebo).
The history of medicine is both a study of medicine throughout history as well as a multidisciplinary field of study that seeks to explore and understand medical practices, both past and present, throughout human societies.
The evolution of clinical research traverses a long and fascinating journey. The recorded history of clinical trials goes back to the biblical descriptions in 500 BC. The journey moves from dietary therapy – legumes and lemons – to drugs.
- Arun Bhatt
- 2010
From the first recorded trial of legumes in biblical times to the first randomized controlled of trial of streptomycin in 1946, the history of clinical trial covers a wide variety of challenges - scientific, ethical and regulatory.
- Arun Bhatt
- 2010
Jan 1, 2014 · This first chapter reviews some of the key historical developments that have led to the current paradigms used in clinical research, such as the concept of randomization, blinding (masking) and, placebo-controls. Scientific inquiry is seeing what everyone else is seeing, but thinking of what no one else has thought.
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Mar 11, 2020 · Here we review the history of clinical trials. We focus specifically on surgical trials along with the ethics and design of randomized controlled trials.
