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  1. Sep 25, 2021 · Supplementation with high doses of vitamin D, known as mega-dose or “stoss therapy,” refers to administering high doses of vitamin D by oral or intramuscular route for short periods of time 14 Shah B.R.

  2. Dec 10, 2021 · Conclusions. Due to various risk factors, many COVID-19 and other patients are at high risk to develop low vitamin D status. If possible, it is reasonable to check their serum 25-hydroxy-vitamin D levels, and only after that, an appropriate dose of vitamin D supplements should be suggested.

    • Andrius Bleizgys
    • Nutrients. 2021 Dec; 13(12): 4415.
    • 10.3390/nu13124415
    • 2021/12
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  4. Dec 23, 2021 · There is consensus that the increase in serum 25 (OH)D depends on the baseline vitamin D status as the change in 25 (OH)D, for a given amount of vitamin D, is highest in vitamin D deficient subjects and gradually diminishes in subjects who are more replete.

  5. There are some data that very high-dose vitamin D therapy may increase the risk of fractures; however, the cause of this is not known . High-dose vitamin D therapy is effective in rapidly raising 25(OH)D concentrations and has historically been used to treat rickets.

    • Ellen M. Smith, Vin Tangpricha, Vin Tangpricha
    • 2015
  6. Dec 11, 2019 · We hypothesized that early administration of high-dose vitamin D 3 (cholecalciferol) would reduce 90-day all-cause, all-location mortality among critically ill, vitamin D–deficient patients...

    • Lung
    • 2019
  7. Feb 9, 2022 · Safety and tolerability of high-dose daily vitamin D3 supplementation in the vitamin D and type 2 diabetes (D2d) study—a randomized trial in persons with prediabetes | European Journal of...

  8. Dec 1, 2021 · Supplementation with high doses of vitamin D, known as mega-dose or “stoss therapy ,” refers to administering high doses of vitamin D by oral or intramuscular route in short periods of time.

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