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  1. www.britannica.com › biography › Greg-WinterGregory P. Winter | Biography, Humanized Antibody, & Phage ...

    Apr 10, 2024 · Gregory P. Winter (born April 14, 1951, Leicester, England) British biochemist known for his development of the first humanized antibodies, his research on the directed evolution of antibodies, and his application of phage display technology for the development of fully human therapeutic antibodies. Winter was awarded the 2018 Nobel Prize in ...

    • Kara Rogers

  2. pubmed.ncbi.nlm.nih.gov › 30888467The 2018 Nobel Prize in Chemistry: phage display of peptides ...

    One-half of the 2018 Nobel Prize in Chemistry was awarded jointly to George P. Smith and Sir Gregory P. Winter "for the phage display of peptides and antibodies". This feature article summarizes significant achievements leading to the development of phage display of peptides and antibodies, where a bacteriophage is genetically modified to ...

    • Rodrigo Barderas, Elena Benito-Peña
    • 2019

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  4. news.cancerresearchuk.org › 2018/10/17 › nobel-prizeNobel Chemistry Prize 2018: how phage display helped generate ...

    Oct 17, 2018 · Winter’s work on phage display has helped to refine that potential. Using phage display, scientists can insert DNA recipes for different shaped antibodies into the phage, creating a library of potential antibodies that will stick to different targets. They can use this library to fish out antibodies that bind most strongly to a drug target.

  5. www.ncbi.nlm.nih.gov › pmc › articlesEditorial: Phage display: Technique and applications - PMC

    Dec 6, 2022 · In 2018, one-half of the Nobel Prize in chemistry was awarded jointly to George P. Smith and Sir Gregory P. Winter for the “phage display of peptides and antibodies” (Smith, 2019; Winter, 2019). Phage display has been widely used to map epitopes, identify drug targets (Takakusagi et al., 2020 ), and develop therapeutics, diagnostics, and ...

  6. www.cam.ac.uk › research › newsSir Greg Winter wins the 2018 Nobel Prize in Chemistry

    Oct 3, 2018 · Sir Greg Winter, of the University of Cambridge, has been jointly awarded the 2018 Nobel Prize in Chemistry, along with Frances Arnold and George Smith, for his pioneering work in using phage display for the directed evolution of antibodies, with the aim of producing new pharmaceuticals. It came as a bit of a shock, and I felt a bit numb for a ...

  7. www.nature.com › articles › d41586/018/06753-yTest-tube’ evolution wins Chemistry Nobel Prize - Nature

    Oct 3, 2018 · Matthew Warren. Gregory Winter (left), Frances Arnold and George Smith share this year’s Nobel Prize in Chemistry. Credit: L–R: Aga Machaj; Caltech; Univ. Missouri-Columbia. Ways to speed up ...

  8. www.thelancet.com › pdfs › journalsPhage display pioneers awarded Nobel Prize - The Lancet

    and Sir Gregory Winter (University of Cambridge, UK), for developing phage display. “Antibodies evolved using phage display can combat autoimmune diseases and in some cases cure metastatic cancer”, noted the Nobel Committee. Smith started working with phages in the early 1980s. “I was exploring phages as a cloning vector for a very ordinary

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