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- After surviving a bomb, a hospital shooting, a plane crash and countless life-or-death situations, Meredith Grey is saying goodbye to Seattle. The Feb. 23 episode marks the last time Ellen Pompeo stars as the show's main character, and fans are now about to find out what "Grey's Anatomy" is like without Grey.
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- Preston Burke (Isaiah Washington) — Season 3. Preston Burke left Grey's at the end of Season 3, abandoning Cristina Yang (Sandra Oh) at the altar to seemingly disappear into thin air.
- Addison Montgomery (Kate Walsh) — Season 3. Addison Montgomery left Seattle to work at Seaside Health & Wellness Center in Los Angeles for ABC's spinoff series Private Practice, which ran for six seasons.
- Erica Hahn (Brooke Smith) — Season 5. Just after Dr. Erica Hahn started a relationship with Callie (Sara Ramirez), Brooke Smith was given the ax via a storyline that sees her character simply walking away from Seattle Grace.
- George O'Malley (T.R. Knight) - Season 6. George O'Malley, a sweet, mostly selfless friend to all, was one of the original interns at the hospital formerly known as Seattle Grace.
May 30, 2024 · Over the past two decades, Grey’s Anatomy has turned season finale cliffhangers into an art form and, closing out its milestone 20th season, the venerable medical drama did not disappoint.
Feb 24, 2023 · Episode 7 of Season 19 marks the last time Ellen Pompeo stars as Meredith Grey in "Grey's Anatomy". Here's how Meredith leaves Grey Sloan Memorial Hospital.
- Maddie Ellis
- Weekend Editor
- Isaiah Washington's Preston Burke – Season 3
- Kate Walsh’s Addison Montogomery – Season 3
- Brooke Smith’s Erica Hahn – Season 5
- T.R. Knight’s George O’Malley – Season 6
- Katherine Heigl’s Izzie Stevens – Season 6
- Chyler Leigh’s Lexie Grey – Season 8
- Eric Dane’s Mark Sloan – Season 9
- Sandra Oh’s Cristina Yang – Season 10
- Patrick Dempsey’s Derek Shepherd – Season 11
- Sandra Ramirez’s Callie Torres – Season 12
Isaiah Washington played Preston Burke, the Head of Cardiothoracic Surgery at Seattle Grace Hospital. Burke was in a relationship with Cristina Yang and got engaged, but he left her on their wedding day and quit immediately after, leaving Grey’s Anatomy in season 3. Burke returned in season 10 to offer Cristina his spot at the medical research inst...
Addison Montgomery was the head of neonatal surgery and obstetrics and gynecology, and Derek Shepherd’s (Patrick Dempsey) ex-wife who had an affair with his best friend, Mark Sloan (Eric Dane). Addison left Grey’s Anatomy in season 3 to star in the spinoff TV series Private Practice, and she returned for a couple of episodes in season 18. Walsh lef...
Erica Hahn was a cardiothoracic surgeon at Seattle Grace and a long-time rival of Preston Burke. She got involved with Callie Torres (Sara Ramirez), but their relationship was complicated and didn’t last long as Callie was still figuring her sexuality out. Hahn’s departure from Grey’s Anatomywas very abrupt, as she simply quit, got into her car, an...
T.R. Knight’s George O’Malley was one of Meredith’s fellow interns in Grey’s Anatomy, and he quickly became a fan favorite. George struggled to find his path, and he suddenly decided to join the U.S. Army in Iraq. Richard Webber gave him his last day off so he could spend time with his family, but on his way home, he jumped in front of a bus to sav...
Izzie Stevens was also one of the interns whose journey began alongside Meredith’s in Grey’s Anatomy season 1. Izzie was diagnosed with cancer in season 5 and eventually recovered, but she was fired sometime later after giving the wrong dosage of medicine to a patient. Izzie left Grey’s Anatomy in season 6, moving to Seattle to start a new life and...
Lexie Grey was Meredith’s half-sister, and she joined Grey’s Anatomy in season 3. Lexie’s death was one of the most tragic ones in the show’s history, as it was a result of one of the most traumatic events in the series: the plane crash. Lexie was crushed by a piece of the plane, injuring her pelvis, legs, and left arm, and died minutes after being...
Mark Sloan was the head of plastic surgery at Seattle Grace Mercy West Hospital, and just like Lexie, he died as a result of injuries from the plane crash. Cristina did her best to help Mark until they were rescued, but in Grey’s Anatomy season 9 premiere episode, Mark was on life support, and as determined by his will, the machines were turned off...
Cristina Yang was also an intern alongside Meredith, and she became one of the most important characters in Grey’s Anatomyas she was Meredith’s best friend and “person”. Cristina’s time to leave Seattle and the series came when Burke offered her a job as the head of the hospital he founded in Switzerland, and as she had always been fiercely competi...
One of the most shocking and heartbreaking deaths in Grey’s Anatomy was Derek Shepherd’s, as he and Meredith were the show’s main couple. After a lot of trouble in their marriage, Derek decided to move back to Seattle from DC, but on his way to DC to resign, he got into a car accident. Derek couldn’t be saved, and he was removed from life support. ...
Callie Torres was the head of Orthopedic Surgery, but Grey’s Anatomy paid more attention to her personal life, as she was in an on-again-off-again relationship with Mark Sloan, got involved with Erica Hahn, and married and later divorced Arizona Robbins (Jessica Capshaw), though that wasn’t the end of their relationship. Callie moved to New York wi...
- Adrienne Tyler
- Senior Staff Writer
May 18, 2023 · The Grey's Anatomy season 19 finale welcomed back Ellen Pompeo's Meredith, Kelly McCreary's Maggie and ended on a cliffhanger with Kim Raver's Teddy.
May 31, 2024 · In its Season 20 finale Thursday, the long-running ABC drama dropped on its viewers along with its doctors a surprise pregnancy, an amnesiac fiancée, an outta-nowhere near kiss and enough pink...
Apr 9, 2024 · It wouldn’t have been that far-fetched if Grey's Anatomy had ended after Season 10. Season 10 had such finality to it, as the show was quite literally closing a major chapter in saying goodbye...
