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Colony-stimulating factors ( CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of committed progenitors [1] in the bone marrow, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate into a specific kind of blood cell (usually white blood cells.
Because of its abilities to attenuate chronic neuroinflammation, promote the production of BDNF, stimulate neurogenesis in the hippocampus and mobilize bone marrow mesenchymal cells that can integrate into the brain and differentiate into neurons, administration of G-CSF has been proposed as a particularly effective strategy for preventing the ...
- 10.1016/j.smim.2021.101511
- 2021/04
Colony stimulating factors (CSFs) are a family of glycoproteins that promote growth and differentiation of hematopoietic progenitor cells and also enhance the function of the mature blood cells, production of CSFs is under tight control since either their over- or underproduction will result in dysregulation of hematopoiesis.
- M. Akashi, H. P. Koeffler
- 1992
Jun 28, 2019 · Colony-stimulating factors (CSF) are intriguing molecules, which are glycoproteins that control the production and even some functions of granulocytes and macrophages, the immune cells that are...
Key Points. Colony-stimulating factors (CSFs) — granulocyte/macrophage CSF (GM-CSF), macrophage CSF (M-CSF) and granulocyte CSF (G-CSF) — have wider functions than their original in vitro...
- John A. Hamilton
- 2008
Jun 18, 2020 · The Colony Stimulating Factors. Discovery, Development, and Clinical Applications. Donald Metcalf, MD. T HE COLONY STIMULATING FACTORS (CSFs) are four. glycoprotein regulators able to control the prolifer- ation and differentiation of granulocytes, monocyte-mac- rophages, and certain related hemopoietic cells.
Jan 1, 1996 · Increased serum levels of granulocyte colony-stimulating factor after autologous bone marrow or blood stem cell transplantation.
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