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- Colony stimulating factors are glycoproteins that promote production of white blood cells (mainly granulocytes such as neutrophils), in response to infection. Administration of exogenous colony stimulating factors stimulates the stem cells in the bone marrow to produce more of the particular white blood cells.
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This review summarizes the cellular sources, patterns of expression and physiological roles of the macrophage (CSF-1, IL-34), granulocyte-macrophage (GM-CSF) and granulocyte (G-CSF) colony stimulating factors within the nervous system, with a particular focus on their actions on microglia.
- 10.1016/j.smim.2021.101511
- 2021/04
Oct 29, 2020 · Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation.
- Kevin M C Lee, Adrian A Achuthan, John A Hamilton
- 2020
Dec 7, 2017 · Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein first recognized for its ability to facilitate the formation of neutrophilic granulocyte colonies in soft agar from bone marrow cells [1, 2]. Endogenous production of G-CSF is largely stimulated by infection and tissue damage.
- Craig R. Wright, Alister C. Ward, Aaron P. Russell
- 10.1155/2017/7517350
- 2017
- Mediators Inflamm. 2017; 2017: 7517350.
Colony-stimulating factors (CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of hemopoietic stem cells, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate into a specific kind of blood cell (usually white blood cells).
Jul 19, 2021 · Meisel C, Schefold JC, Pschowski R, Baumann T, Hetzger K, Gregor J, et al. Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind ...
- Xiuying Mu, Kai Liu, Kai Liu, Huajie Li, Fu-Sheng Wang, Fu-Sheng Wang, Ruonan Xu
- 2021
Colony-stimulating factors ( CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of committed progenitors [1] in the bone marrow, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate into a specific kind of blood cell (usually white blood cells.
The colony stimulating factors (CSFs) comprise a small family of homodimeric cytokines central to blood formation, leukocyte function, and overall immune competence. Family members include macrophage-CSF (M-CSF), granulocyte-CSF (G-CSF), granulocyte/macrophage-CSF (GM-CSF), and interleukin-3 (IL-3).
