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      • Idiosyncratic adverse drug reactions (IADRs) encompass a diverse group of toxicities that can vary by drug and patient. The complex and unpredictable nature of IADRs combined with the fact that they are rare makes them particularly difficult to predict, diagnose, and treat.
  1. The term idiosyncratic drug reaction (IDR) has been used in various ways and has no clear definition, but the term is used in this review to designate an adverse reaction that does not occur in most patients treated with a drug and does not involve the therapeutic effect of the drug.

    • PubMed

      Idiosyncratic drug reactions are a significant cause of...

    • PMC Free Article

      Idiosyncratic Adverse Drug Reactions. An important subset of...

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  3. Jun 25, 2020 · Idiosyncratic adverse drug reactions (IADRs) encompass a diverse group of toxicities that can vary by drug and patient. The complex and unpredictable nature of IADRs combined with the fact that they are rare makes them particularly difficult to predict, diagnose, and treat.

    • Merrie Mosedale, Paul B Watkins
    • 2020
  4. Mar 8, 2013 · Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients; they also markedly increase the uncertainty of drug development. The major targets are skin, liver, and bone marrow. Clinical characteristics suggest that IDRs are immune mediated, and there is substantive ….

  5. Aug 20, 2012 · Idiosyncratic adverse drug reactions (IADRs) in humans can result in a broad range of clinically significant toxicities leading to attrition during drug development as well as postlicensing withdrawal or labeling. IADRs arise from both drug and patient related mechanisms and risk factors.

    • Richard A. Thompson, Emre M. Isin, Yan Li, Lars Weidolf, Ken Page, Ian Wilson, Steve Swallow, Brian ...
    • 2012
  6. Oct 10, 2022 · The most common type of IDR leading to drug candidate failure is idiosyncratic drug-induced liver injury (IDILI), and most drug metabolism occurs in the liver. If reactive metabolites are responsible for IDRs, screening for their formation should lead to safer drug candidates.

    • Jack Uetrecht, *
    • 2022/10/10
    • 10.1021/acs.chemrestox.2c00090
  7. Feb 9, 2020 · Idiosyncratic adverse drug reactions (IADRs) encompass a diverse group of toxicities that can vary by drug and patient. The complex and unpredictable nature of IADRs...

  8. Jun 10, 2010 · Idiosyncratic Adverse Drug Reactions. An important subset of ADRs that cause DILI are idiosyncratic adverse drug reactions (IADRs), which account for about 13% of all cases of acute liver failure (Ostapowicz et al., 2002).

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