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- Often large, bulky, intramural masses Fish flesh or tannish brown parenchyma with hemorrhage, necrosis and cystic softening Microscopic (histologic) description Mesenchymal tumor usually centered in the muscularis propria
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The histologic features of rectal GISTs are intermediate between small intestinal and gastric GISTs, with most tumors having spindle cell morphology, but occasional epithelioid GISTs similar to those seen in the stomach are also seen in the rectum .
- Markku Miettinen, Jerzy Lasota
- 10.1002/jso.21945
- 2011
- 2011/12
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Jan 8, 2018 · GISTs are the most common mesenchymal neoplasms of the gastrointestinal tract and can have spindle-cell or epithelioid histology; 80% express the KIT protein and 10% express platelet-derived growth factor receptor alpha (PDGFRA) ( 2, 3 ).
- Hitoshi Kameyama, Tatsuo Kanda, Yosuke Tajima, Yoshifumi Shimada, Hiroshi Ichikawa, Takaaki Hanyu, T...
- 10.21037/tgh.2018.01.08
- 2018
- Transl Gastroenterol Hepatol. 2018; 3: 8.
Feb 24, 2021 · Definition / general. Tumors that differentiate along lines of interstitial cells of Cajal, the gut's pacemaker cells ( Mod Pathol 2003;16:366 ) Essential features. Mesenchymal spindle cell neoplasm caused by KIT or PDFRGA mutations. Risk stratification is based on location, size and mitotic rate.
Aug 20, 2018 · GISTs have three different histologic findings, including spindle (70%) (Figure 6A), epithelioid (20%) (Figure 6B), or mixed type (10%). They are often misdiagnosed as leiomyoma or leiomyosarcoma prior to immunohistochemical analysis ( 3 ).
- Trisha M. Parab, Michael J. DeRogatis, Alexander M. Boaz, Salvatore A. Grasso, Paul S. Issack, David...
- 10.21037/jgo.2018.08.20
- 2018
- 2019/02
Apr 11, 2023 · Most GISTs harbor characteristic mutations in KIT or platelet-derived growth factor receptor alpha (PDGFRA), while mutations in succinate dehydrogenase (SDH) or other genes are less frequent. The clinical presentation, diagnosis, and prognosis of GISTs will be discussed here.
Gastrointestinal stromal tumours (GISTs) are malignant mesenchymal tumours with a variable clinical behaviour, marked by differentiation towards the interstitial cells of Cajal. 1 GISTs belong to the family of soft tissue sarcomas (STSs) but are treated separately due to their peculiar histogenesis, clinical behaviour and specific therapy.
Gain-of-function mutations in KIT or PDGFRA receptor tyrosine kinases are the crucial drivers of most GISTs, responsible for tumor initiation and evolution throughout the entire course of the disease.
