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Jul 1, 2022 · The KDIGO 2020 guideline (5) provides excellent information on medication therapy recommendations for people with diabetes and CKD. An ACE inhibitor or ARB is recommended as first-line therapy for people with diabetes, hypertension, and albuminuria and should be titrated to a maximum tolerated dose.
Aug 1, 2003 · In this study, we describe a drastic reduction of urinary levels of the chemokine MCP-1 in patients with diabetic nephropathy who were treated with the ACEI lisinopril. Furthermore, the observed improvement in proteinuria correlated well with the reduction of MCP-1 levels.
Jun 28, 2008 · Diabetic nephropathy, a common complication in patients with type 2 diabetes, is the leading cause of end‐stage renal disease (ESRD) in the United States. 1 Angiotensin‐converting enzyme (ACE) inhibitors have been considered agents of choice for providing protection against the progression of kidney disease for patients with type 1 diabetes ...
EVIDENCED-BASED ANSWER. Lisinopril dosed at least 10 mg daily decreases risk for progression from micro- to macroalbuminuria in patients with cardiovascular risk factors including diabetes (SOR: B, meta-analysis of RCTs).
May 3, 2017 · Numerous trials have shown that ACE inhibitors decrease microalbuminuria and slow progression of diabetic nephropathy in patients with both type 1 and type 2 diabetes. Captopril is the only FDA-approved ACE inhibitor for diabetic nephropathy although other ACE inhibitors may be as effective.
Oct 3, 2022 · Consensus Statement. Metformin is recommended for patients with T2D, CKD, and eGFR ≥30 mL/min/1.73 m 2; the dose should be reduced to 1,000 mg daily for patients with eGFR 30–44 mL/min/1.73 m 2 and for some patients with eGFR 45–59 mL/min/1.73 m 2 who are at high risk of lactic acidosis.
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Jul 17, 2024 · Most guidelines recommend estimation of GFR and albuminuria at least annually in people with diabetes to detect the development of DKD. (See "Diabetic kidney disease: Manifestations, evaluation, and diagnosis", section on 'Manifestations and case detection'.)
