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  1. 1. a. : a sudden advance especially in knowledge or technique. a medical breakthrough. b. : a person's first notable success often used before another noun. a breakthrough novel. the actress's breakthrough performance. 2. a. : an act or instance of moving through or beyond an obstacle. a breakthrough in the talks between the region's leaders.

  2. an important discovery or event that helps to improve a situation or provide an answer to a problem: Scientists are hoping for a breakthrough in the search for a cure for cancer. A major breakthrough in negotiations has been achieved. More examples. Fewer examples.

  3. an important discovery or event that helps to improve a situation or provide an answer to a problem: Scientists are hoping for a breakthrough in the search for a cure for cancer. A major breakthrough in negotiations has been achieved. More examples. Fewer examples.

  4. Breakthrough is a 2019 American Christian drama film directed by Roxann Dawson in her feature film directorial debut. The film was written by Grant Nieporte, based on the Christian book The Impossible, an account of true events written by Joyce Smith with Ginger Kolbaba.

  5. noun. a military movement or advance all the way through and beyond an enemy's frontline defense. an act or instance of removing or surpassing an obstruction or restriction; the overcoming of a stalemate: The president reported a breakthrough in the treaty negotiations.

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  7. An amazing discovery or a huge amount of progress can be called a breakthrough. The discovery of penicillin in 1928 was a breakthrough for modern medicine. A personal breakthrough might be overcoming your fear of spiders once and for all.

  8. breakthrough. noun. Definition of breakthrough. as in improvement. an instance of notable progress in the development of knowledge, technology, or skill Alexander Fleming's discovery of penicillin was one of medicine's great breakthroughs, for penicillin became the first antibiotic to successfully combat bacterial infections in humans.

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