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- OverviewSep 19, 2005-May 22, 200625 episodesEpisodes25. One of Our Own May 22, 2006
- Revelation of the mole's identity jeopardizes the future of the lab.
- 24. Rampage May 15, 2006
- Horatio and the team are on the verge of putting away members of the dangerous Mala Noche gang.
- 23. Shock May 8, 2006
- A spoiled heiress is found dead in her bathtub during her own party.
- 22. Open Water May 1, 2006
- The team searches for the killer of two people on a cruise ship docked in Miami.
- 21. Dead Air Apr 24, 2006
- A kidnapped woman misdials a cell-phone number and begs for help.
- 20. Free Fall Apr 10, 2006
- The CSI team must find whoever is trying to kill a couple recently released from jail.
- 19. Driven Mar 20, 2006
- Horatio must protect Marisol when her life is threatened after she witnesses a robbery.
- 18. Double Jeopardy Mar 13, 2006
- When a corpse is recovered, the team suspects a man formerly vindicated of killing his wife.
- 17. Collision Mar 6, 2006
- Horatio must ask Natalia to reveal a secret from her past to help solve a murder.
- 16. Deviant Feb 27, 2006
- A convicted child molester is found murdered in Alexx's neighborhood.
- 15. Skeletons Feb 6, 2006
- When a body is found on the beach, the evidence leads points to Walter Resden.
- 14. Fade Out Jan 30, 2006
- Evidence links a series of murders to organized crime and a pair of film students.
- 13. Silencer Jan 23, 2006
- The ruthless Mala Noche gang strikes again and the team must track them down once and for all.
- 12. The Score Jan 9, 2006
- A man is murdered while trying to learn how to pick up women at a hip Miami nightclub.
- 11. Payback Dec 19, 2005
- New technology helps find the true rapist in a cold case, but he is murdered before the trial.
- 10. Shattered Nov 28, 2005
- Horatio and his team investigate the murder of a suspected drug lord.
- 9. Urban Hellraisers Nov 21, 2005
- The team searches for a group of video gamers that has started to play the game in real life.
- 8. Nailed Nov 14, 2005
- Ryan's life is in jeopardy when the team is caught in the midst of a deadly divorce case.
- 7. Felony Flight Nov 7, 2005
- A convicted murderer escapes and begins to kill again; the original arresting officer returns.
- 6. Under Suspicion Oct 24, 2005
- The team tries to find the person who framed Horatio for the murder of a woman he has been dating.
- 5. Three-Way Oct 17, 2005
- Three vacationing housewives are the prime suspects when their hotel's pool boy is murdered.
- 4. 48 Hours to Life Oct 10, 2005
- Horatio believes that a confessed killer is actually innocent.
- 3. Prey Oct 3, 2005
- When a teenage tourist goes missing, the team investigates the dark side of Miami's nightclub scene.
- 2. Blood in the Water Sep 26, 2005
- A couple's daughter dies when the family is trapped on a burning yacht in shark-infested waters.
- 1. From the Grave Sep 19, 2005
- When Horatio attacks a smuggling operation, he becomes a target.