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- Season 6 overviewSep 23, 2009-May 26, 201023 episodesSeason 6 episodes1. Epilogue Sep 23, 2009
- A shooting and its aftermath drastically change the life of a member of the team.
- 2. Blacklist (Featuring Gravedigger) Sep 30, 2009
- The team searches for a cyber killer who seems to be targeting medical health care workers.
- Mac and the team follow the trail of evidence left by a killer after two bodies are found.
- 4. Dead Reckoning Oct 14, 2009
- DNA evidence contradicts the confession of a scorned woman who claimed to have murdered her husband.
- 5. Battle Scars Oct 21, 2009
- A shooting victim is a rising star in the world of hip-hop dance battles.
- 6. It Happened to Me Nov 4, 2009
- An executive from a software company bleeds to death on a Manhattan street.
- 7. Hammer Down Nov 11, 2009
- An accident reveals an interstate trucking ring specializing in black market organ harvesting.
- 8. Cuckoo's Nest Nov 18, 2009
- The CSIs finds a compass near a body that fell from the 59th Street Bridge.
- 9. Manhattanhenge Nov 25, 2009
- As the team races to save the Compass Killer's fourth victim, the sunrise presents a final surprise.
- 10. Death House Dec 9, 2009
- A911 call sends the CSIs to a vacant penthouse, where they unearth a nearly century-old corpse.
- 11. Second Chances Dec 16, 2009
- The team investigates when a reformed drug addict is found dead in an alley.
- 12. Criminal Justice Jan 13, 2010
- The team discovers planted evidence while investigating a stabbing.
- 13. Flag on the Play Jan 20, 2010
- The quarterback of a women's football team is found dead in the locker room.
- 14. Sanguine Love Feb 3, 2010
- A murder investigation takes the CSIs into a subculture of vampirism.
- 15. The Formula Feb 10, 2010
- The CSIs discover that car tampering led to the explosion that killed a racing legend.
- 16. Uncertainty Rules Mar 3, 2010
- After a man's friends turn up dead, he is found covered in their blood.
- 17. Pot of Gold Mar 10, 2010
- A double homicide involving two journalists occurs on the eve of St. Patrick's Day.
- 18. Rest in Peace, Marina Garito Apr 7, 2010
- Stella risks her life to solve the case of a woman, linked to an unsolved murder, is found dead.
- 19. Redemption Apr 14, 2010
- A death row inmate's final request brings Dr. Hawkes to a prison just as a riot erupts.
- 20. Tales From the Undercard May 5, 2010
- An investigation takes the team into the underground world of hardcore fighting.
- 21. Unusual Suspects May 12, 2010
- Mac is determined to seek justice when a 14-year-old boy is shot in front of his brother.
- 22. Point of View May 19, 2010
- While at home recuperating from an injury, Mac witnesses mysterious behavior that leads to a murder.
- 23. Vacation Getaway May 26, 2010
- An escaped criminal's plans put Danny's and Lindsay's lives in danger.