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The Catholic Monarchs were Queen Isabella I of Castile (r. 1474–1504) and King Ferdinand II of Aragon (r. 1479–1516), whose marriage and joint rule marked the de facto unification of Spain. They were both from the House of Trastámara and were second cousins, being both descended from John I of Castile; to remove the obstacle that this consanguinity would otherwise have posed to their marriage unde... Wikipedia