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Nov 18, 2020 · DCX-based fate mapping of NPCs reveals oligodendroglial potential in the adult hippocampus. Fate mapping analysis in DCX-CreER T2 /Flox-EGFP mice revealed a small number of GFP + Olig2 + CC1 + cells in healthy controls. This suggests that, even under physiological conditions, a small percentage of mature oligodendrocytes in the hippocampal DG ...
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The DCX gene provides instructions for producing a protein called doublecortin. This protein is involved in the movement of nerve cells (neurons) to their proper locations in the developing brain, a process called neuronal migration. Doublecortin attaches (binds) to microtubules, which are rigid, hollow fibers that make up the cell's structural ...
Nov 18, 2020 · The aim of this study was to investigate whether hippocampal DCX + NPCs can generate new oligodendrocytes under conditions in which myelin repair is required. For this, the cell fate of DCX-expressing NPCs was analyzed during cuprizone-induced demyelination and subsequent remyelination in two regions of the hippocampal dentate gyrus of DCX ...
Jun 1, 2015 · DCX-Immunoreactive Cell Counting and Reconstruction. All DCX-immunoreactive (IR) multipolar cells present in the OT of S (n = 5) and CTRL (n = 5) individuals were counted using a Leitz microscope and 40x (NA 0.75) objective, and data expressed as absolute counts of cells and process bundles. Bundles were defined as groupings of DCX-IR processes ...
Jun 28, 2017 · DCX is essential for the development of a functional brain. DCX is a 40 kDa phosphoprotein encoded by the DCX gene. It is a nervous system-specific MAP expressed in migrating neurons of the central and peripheral nervous system during embryonic and postnatal development (Gleeson et al., 1999).
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