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DWLS: Gene Expression Deconvolution Using Dampened Weighted Least Squares. Dampened weighted least squares (DWLS) is an estimation method for gene expression deconvolution, in which the cell-type composition of a bulk RNA-seq data set is computationally inferred.
Jul 5, 2019 · Nature Communications - Bulk RNA-seq data harbors valuable information about gene expression levels from different cell types in tissue samples. Here, the authors develop DWLS, a computational...
- Daphne Tsoucas, Rui Dong, Haide Chen, Qian Zhu, Guoji Guo, Guo-Cheng Yuan
- 2019
May 10, 2021 · SpatialDWLS is an extension of dampened weighted least squares (DWLS) , which we developed previously for deconvolution of RNAseq data. In short, DWLS uses a weighted least squares approach to infer cell-type composition, where the weight is selected to minimize the overall relative error rate.
- Rui Dong, Guo-Cheng Yuan, Guo-Cheng Yuan
- 2021
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Nov 6, 2020 · Nature Communications - Inferring cell type proportions from transcriptomics data is affected by data transformation, normalization, choice of method and the markers used. Here, the authors use...
- Francisco Avila Cobos, Francisco Avila Cobos, José Alquicira-Hernandez, José Alquicira-Hernandez, Jo...
- 2020
Jan 14, 2021 · Summary of DWLS Penalties. The criminal offense of driving with a suspended or revoked driver license can result in a civil infraction, or a criminal charge for a second degree misdemeanor, a first degree misdemeanor, or even a third degree felony.
Jan 19, 2022 · Open access. Published: 19 January 2022. Advances in mixed cell deconvolution enable quantification of cell types in spatial transcriptomic data. Patrick Danaher, Youngmi Kim, Brenn Nelson, Maddy...
Perform DE analysis using MAST. Dampened weighted least squares (DLWS) is an estimation method for gene expression deconvolution, in which the cell-type composition of a bulk RNA-seq data set is computationally inferred.
