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Crazed real estate tycoon Vivian Dimitri (Helen Shaver) seeks retribution for her husband's death in San Quentin by systematically murdering those she believes are responsible. Hot on her trail is Los Angeles police detective Columbo (Peter Falk), who has connected the victims but doesn't have enough evidence to put Vivian behind bars. As Columbo gets closer to cracking the case, Vivian attempts to throw the detective off with a new ploy: killing Mrs. Columbo.