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Barbara Wyatt-Hollis (Joanne Woodward) is a successful college professor who must come to terms with the onset of Alzheimer's disease as it begins to affect her professional life, her marriage to her compassionate husband, George (Richard Kiley), and her grown children. As Barbara's personality and memories disappear, a husband no longer knows the woman he married, a mother (Geraldine Fitzgerald) helplessly watches her daughter's deterioration, and a son's fear and vulnerability consume him. Wikipedia