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1 day ago · We generate four multiplexed orthogonal BE systems that enable rates of precise co-occurring edits of up to 7.1% in the same DNA strand without enrichment or selection strategies. The addition of ...
Apr 29, 2024 · Cytosine base editors (CBEs) catalyze the transition mutation C•G-to-T•A through the deamination of deoxycytidine to deoxyuridine. The U•G mismatch can be repaired to U•A resulting in a T•A base pair. Conjugating the uracil glycosylase inhibitor (UGI) to CBEs increases the editing efficiency and purity [ 2, 3, 4 ].
5 days ago · Guanine. updated: May 17, 2024. Definition. 00:00. … Guanine (G) is one of the four nucleotide bases in DNA, with the other three being adenine (A), cytosine (C) and thymine (T). Within a double-stranded DNA molecule, guanine bases on one strand pair with cytosine bases on the opposite strand.
Apr 25, 2024 · Correction: Application of CRISPR-Based C-to-G base editing in rice protoplasts. Jimin Lee, Nuri Oh, Jae‑Young Yun, Hee Soon Choi, Jang‑Kyun Seo, Jin‑Ho Kang &. Choonkyun Jung. Applied Biological Chemistry 67, Article number: 42 ( 2024 ) Cite this article.
- Jimin Lee
May 6, 2024 · https://doi.org/10.1111/pbi.14358. Sections. PDF. Tools. Share. Editing of the plastid genome helps understand the molecular functions of plastid genes and engineer desired traits in crops (Maliga, 2022 ). The DddA-derived cytosine base editors (DdCBEs) enable C-to-T editing in mitochondrial and plastid genomes (Kang et al ., 2021; Li et al ...
Apr 24, 2024 · BEAN is a Bayesian approach for analyzing base editing screens with improved effect size quantification and variant classification. Applied to low-density lipoprotein (LDL)-associated common ...
Apr 24, 2024 · Nature Biotechnology - Author Correction: Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos
