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Gero Miesenböck. Gero Andreas Miesenböck FRS [10] (born 15 July 1965) [8] is an Austrian scientist. He is currently Waynflete Professor of Physiology and Director of the Centre for Neural Circuits and Behaviour (CNCB) [11] at the University of Oxford and a fellow of Magdalen College, Oxford. [12]
- Gero Andreas Miesenböck, 15 July 1965 (age 58), Austria
- Optogenetics
Waynflete Professor of Physiology. Gero Miesenböck studied medicine at the University of Innsbruck in his native Austria and did postdoctoral research at Memorial Sloan-Kettering Cancer Center in New York. He was on the faculty of Memorial Sloan-Kettering Cancer Center and Yale University before coming to Oxford in 2007. Gero is the founding ...
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- Biography
- Your Father Was Clearly An Early Mentor. Were There Others?
- So How Did You Get Yourself Out of Austria and Over to America?
- What Was Your First Project in The Rothman Lab?
- What Was Your First Project in Your Own Lab?
- When Was That, and Where Were You?
- Where Did The Remote Control Idea Come from?
- Why Did You Choose to Work on The Fly?
- What Are Your Favourite papers?
- And Which of Your Own Papers Are You particularly Fond of?
Gero Miesenböck studied medicine at the University of Innsbruck in his native Austria and did postdoctoral research at Memorial Sloan-Kettering Cancer Center in New York. He was on the faculty of Memorial Sloan-Kettering Cancer Center and Yale University before coming to Oxford in 2007. Gero is the founding director of the CNCB. Gero has invented m...
In 1989, I spent three months at the University of Umeå, near the Arctic Circle, to learn an experimental technique I needed for my dissertation. Unwisely, I had chosen winter for my visit. In the near-complete darkness of northern Sweden, our circadian clocks started to run free. People worked the strangest hours because it didn’t matter when you ...
I wrote to Rothman a year or two later when I was finishing medical school. It didn’t take long until a rejection letter arrived, in which my surname was spectacularly misspelled. Admittedly it is an unusual name, but 4 out of the 10 letters were incorrect. Come on! But I persisted. I visited Felix Wieland, a collaborator of Rothman’s in Heidelberg...
I initially worked on protein sorting in cells. But soon my work concentrated on what has become a recurring theme: the development of biological tools to illuminate biological problems. The first such tool used a light-emitting protein to make communication between nerve cells visible. To get the system to work, I had to isolate the DNA that encod...
The initial aim was to image information flow in a neural circuit with synapto-pHluorin. But then very quickly, in the summer of 1999—it was one of those moments where I can even remember the time and the date and the room I was in—I had the idea of using light not only to observe but also to control. That then quickly became another focus of the l...
It was the late afternoon of June 12, 1999, a Saturday. We were living on Union Square in Manhattan at the time. I had taken a long walk after lunch, come back home, and stretched out on the bed, ready to return to a book I was absorbed in, Independence Day by Richard Ford. As I was reaching for the book, drifting from the real world into Ford’s fi...
I guess I had the advantage of being a newcomer to neurobiology. I was not too weighed down by received wisdom, maybe not too weighed down by neuroscience knowledge in general. But I had worked in a leading cell biology lab. I had seen that to establish causality and dissect a complex mechanism it’s essential to be able to control it. In neuroscien...
The nematode C. elegans has just 302 neurons and a correspondingly, shall we say, basic behavioural repertoire. Rodents are too complex. If you look at a mouse brain under a microscope you instantly realise that you are seeing only a small part of a much bigger structure. In contrast, if you look at a fly brain under a microscope you get the impres...
There’s of course the one discussed in that fateful journal club in Umeå: ‘The rate of bulk flow from the endoplasmic reticulum to the cell surface’ by Felix Wieland, Michael Gleason, Tito Serafini, and Jim Rothman (Cell 1987: 50, 289-300). Another eye-opener was ‘The statistical nature of the acetycholine potential and its molecular components’ by...
Well, there’s the two that laid the foundations of optogenetic control: ‘Selective photostimulation of genetically chARGed neurons’ with Boris Zemelman, Georgia Lee and Minna Ng (Neuron 2002: 33, 15-22), and ‘Remote control of behavior through genetically targeted photostimulation of neurons’ with Susana Lima (Cell 2005: 121, 141-152). Perhaps beca...
The Miesenböck Group at the Centre for Neural Circuits and Behaviour studies how the brain controls behaviour using optogenetics, a technique that allows the manipulation of neural activity with light. Led by Professor Gero Miesenböck, a pioneer and prize-winner in the field, the group investigates the neural mechanisms of learning, memory, sleep and decision-making in fruit flies.
Gero Miesenböck is Waynflete Professor of Physiology and Director of the Centre for Neural Circuits and Behaviour. Gero studied medicine at the University of Innsbruck in his native Austria and did postdoctoral research at Memorial Sloan-Kettering Cancer Center in New York. He was on the faculty of Yale University before coming to Oxford in 2007.
Jul 22, 2016 · Pioneer Gero Miesenböck explains how optogenetics illuminated neuroscience. In 1999, neuroscientist Gero Miesenböck dreamed of using light to expose the brain's inner workings. Two years later ...
Gero Miesenböck studied medicine at the University of Innsbruck in his native Austria and did postdoctoral research at Memorial Sloan-Kettering Cancer Center in New York. He was on the faculty of Memorial Sloan-Kettering Cancer Center and Yale University before coming to Oxford in 2007. Gero is the founding director of the Centre for Neural ...
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