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Oct 10, 2018 · Fig. 1 The viral life cycle of dengue virus (DENV). The virus binds to host cell receptors (exact receptors are unknown) (1) and enters the host cell (DENV permissive cells include keratinocytes, dendritic cells, endothelial cells, fibroblasts, macrophage, and mast cells), via receptor-mediated endocytosis (2).
Feb 25, 2015 · DENV structure and the putative receptors for virus entry. (A) Schematic representation of DENV structure composed of a lipid envelope (orange) with the envelope (E) protein homodimers (green, PDB ID: 1OAN) and the membrane (M) proteins (blue, PDB ID: 4B03), surrounding an amorphous nucleocapsid formed by the ssRNA genome associated to capsid (C) protein homodimers (red, PDB ID: 1R6R).
When a mosquito carrying dengue virus bites a person, the virus enters the skin together with the mosquito's saliva. The virus infects nearby skin cells called keratinocytes , as well as specialized immune cell located in the skin, called a Langerhans cells . [ 45 ]
Apr 22, 2024 · Dengue viruses (DENV) are positive-stranded RNA viruses belonging to the Flaviviridae family. DENV is the causative agent of dengue, the most rapidly spreading viral disease transmitted by mosquitoes. Each year, millions of people contract the virus through bites from infected female mosquitoes of the Aedes species. In the majority of individuals, the infection is asymptomatic, and the immune ...
May 31, 2023 · Many people do not experience symptoms. Common symptoms include fever, muscle pain, headache, loss of appetite, nausea or vomiting. In most cases, symptoms disappear after 3 to 4 days. A small percentage of patients enter a second, more toxic phase within 24 hours of recovering from initial symptoms.
Aug 11, 2021 · Dengue fever is a disease spread by mosquito bites. There’s no vaccine to prevent it. Dengue can be mild or severe.
Apr 18, 2024 · Dengue virus is transmitted to people by mosquitoes infected with the dengue virus. Dengue virus infection (also called dengue fever) involves severe flu-like symptoms. The virus and the types of mosquitos that spread it are found in tropical and sub-tropical countries of Asia, Africa and South America.
