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Mar 27, 2020 · Howard Walter Florey (1898–1968) and Ernst Boris Chain (1906–1979) were the scientists who followed up most successfully on Alexander Fleming’s discovery of penicillin, sharing with him the 1945 Nobel Prize in Physiology or Medicine. Florey and Chain each brought scientific knowledge and talent to the effort that filled out the other’s ...
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While Alexander Fleming is often credited with discovering penicillin in 1928, Howard Walter Florey oversaw initial clinical trials and led the team that first produced large quantities of this antibiotic, which played an important role in the Allied victory in World War II. But the antibacterial activity of penicillin was first discovered decades before Fleming's or Florey's work. Ernest A.C ...
To begin with, Florey was the head of the department and was in a position to direct the resources of the Dunn School to the penicillin project. But, even. more important than this, he was a very practical man and saw at once that a successful. outcome would be achieved only by the collaboration of several hands.
However, the strain had been saved at Oxford. In 1939, Howard Florey assembled a team, including a fungal expert, Norman Heatley, who worked on growing Penicillium spp. in large amounts, and Chain, who successfully purified penicillin from an extract from the mold. Florey oversaw the animal experiments.
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