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Loren David Walensky. Professor of Pediatrics. The Walensky laboratory focuses on the chemical biology of deregulated apoptotic and transcriptional pathways in cancer. Our goal is to develop an arsenal of new compounds-a “chemical toolbox”-to investigate and block protein interactions that cause cancer. To achieve these objectives, we take ...
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486. 2010. The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members. GL Verdine, LD Walensky. Clinical cancer research 13 (24), 7264-7270. , 2007. 475. 2007. Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma.
About Us. The Walensky laboratory specializes in the chemical biology of deregulated apoptotic, transcriptional, and metabolic pathways in cancer, emphasizing the chemical, structural, and cell biology of the BCL-2 family signaling network. To facilitate our research, we have developed and applied stapled peptides that preserve the structure of ...
Takada K, Zhu D, Bird GH, Sukhdeo K, Zhao JJ, Mani M, Lemieux M, Carrasco DE, Ryan J, Horst D, Fulciniti M, Munshi NC, Xu W, Kung AL, Shivdasani RA, Walensky LD, Carrasco DR. Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling. Sci Transl Med 2012; 4:148ra117. PubMed; Walensky LD. Interview with Loren D Walensky.
Dr. Loren Walensky is a Professor of Pediatrics at Harvard Medical School, Principal Investigator and Attending Physician in the Department of Pediatric Oncology at the Dana-Farber Cancer Institute/Boston Children’s Hospital, and Director of the Harvard/MIT MD-PhD Program. He serves as an adjunct faculty member in the Department of Cancer ...
R21CA209358 (WALENSKY, LOREN DAVID) Jun 2, 2016 - May 31, 2018. NIH. Biophysical and Mechanistic Determinants for Cancer Cell Import of Hydrocarbon-Stapled Peptides. Role: Principal Investigator. R35CA197583 (WALENSKY, LOREN DAVID) Aug 10, 2015 - Jul 31, 2028.
