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Louise of Savoy (11 September 1476 – 22 September 1531) was a French noble and regent, Duchess suo jure of Auvergne and Bourbon, Duchess of Nemours and the mother of King Francis I and Marguerite of Navarre. She was politically active and served as the regent of France in 1515, in 1525–1526 and in 1529, during the absence of her son. Wikipedia