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- Season 4 overviewSep 20, 2016-May 16, 201722 episodesSeason 4 episodes1. The Ghost Sep 20, 2016
- Coulson and Mack team up to confirm the presence of Inhumans; May needs to train strike teams.
- 2. Meet the New Boss Sep 27, 2016
- Daisy sets out to battle Ghost Rider; the new director's bold agenda shocks everyone.
- 3. Uprising Oct 11, 2016
- Coulson, Mack and Fitz try to locate and neutralize a group looking to stop Inhuman registration.
- 4. Let Me Stand Next to Your Fire Oct 18, 2016
- Ghost Rider's thirst for vengeance results in an explosive confrontation with S.H.I.E.L.D.
- 5. Lockup Oct 25, 2016
- S.H.I.E.L.D. breaks into a high-security prison to decipher the secrets.
- 6. The Good Samaritan Nov 1, 2016
- The shocking origin story of Robbie's transition into Ghost Rider is revealed.
- 7. Deals With Our Devils Nov 29, 2016
- The remaining members of the team look for answers as time begins to run out for Ghost Rider.
- 8. The Laws of Inferno Dynamics Dec 6, 2016
- S.H.I.E.L.D. and Ghost Rider work together to save the lives of everyone in Los Angeles.
- 9. Broken Promises Jan 10, 2017
- Coulson is unaware of a dark secret May is hiding; Aida is determined to find the Darkhold.
- 10. The Patriot Jan 17, 2017
- Coulson and Mack discover a secret about Mace, which puts all of S.H.I.E.L.D. in a dangerous spot.
- 11. Wake Up Jan 24, 2017
- May works to uncover the truth about what happened to her; Aida's next move puts everyone at risk.
- 12. Hot Potato Soup Jan 31, 2017
- Coulson and the team race to save agents Sam and Bill Koenig and the Darkhold book.
- 13. BOOM Feb 7, 2017
- Daisy, Mace and the team seek a way to contain an explosive Inhuman.
- 14. The Man Behind the Shield Feb 14, 2017
- Coulson and the team engage in a deadly cat-and-mouse game as they work to rescue Director Mace.
- 15. Self Control Feb 21, 2017
- As more LMDs infiltrate S.H.I.E.L.D., suspicion begins to turn to paranoia among the team.
- 16. What If... Apr 4, 2017
- Daisy and Simmons are the only hope to save everyone in a world controlled by Hydra.
- 17. Identity and Change Apr 11, 2017
- Daisy and Simmons struggle to discover an escape route to the real world.
- 18. No Regrets Apr 18, 2017
- The truth behind Fitz's turn threatens to bring down all of S.H.I.E.L.D.
- 19. All the Madame's Men Apr 25, 2017
- Daisy teams up with an unlikely partner; Aida prepares to put her endgame into effect.
- 20. Farewell, Cruel World! May 2, 2017
- Daisy and Simmons race against the clock to get the team out of the Framework.
- 21. The Return May 9, 2017
- A new and deadlier enemy looms against Coulson and the team after the victory in the Framework.
- 22. World's End May 16, 2017
- Ghost Rider makes a surprising return; Coulson and the team work to stop Aida from ending the world.