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  1. Premise. The series explores the research and the relationship between William Masters ( Michael Sheen) and Virginia Johnson ( Lizzy Caplan ), two pioneering researchers of human sexuality at Washington University in St. Louis, Missouri. [4] The series begins in October 1956 and ends in August 1969 with the fourth season.

    • September 29, 2013 –, November 13, 2016
    • Showtime
  2. See Full Cast & Crew. Find out how to watch Masters of Sex. Stream the latest seasons and episodes, watch trailers, and more for Masters of Sex at TV Guide.

    • (69)
    • 5
    • TVMA
  3. Buy Masters of Sex on Fandango at Home, Prime Video. William Masters and Virginia Johnson are known as pioneers of the science of human sexuality. Their research shoots them to fame on a ...

    • Michael Sheen
    • TV-MA
    • 4
    • Masters of Sex1
    • Masters of Sex2
    • Masters of Sex3
    • Masters of Sex4
    • Masters of Sex5
  4. Buy Masters of Sex — Season 1 on Fandango at Home, Prime Video. Seductive and nuanced, Masters of Sex features smart performances, deft direction, and impeccable period decor. Read...

    • (29)
    • Michael Sheen
    • Jennifer Getzinger
    • September 29, 2013
  5. Masters of Sex tells the story of Dr. William Masters (Michael Sheen) and Virginia Johnson (Lizzy Caplan), two pioneering researchers of human sexuality at Washington University in St. Louis. The first season takes place between 1956 and 1958.

  6. Sep 29, 2013 · Masters (Michael Sheen) privately treats a couple for infertility, without revealing his relationship to them. Johnson (Lizzy Caplan) realizes her work with Masters can be used to help people...

  7. Sep 29, 2013 · Starring Michael Sheen, Lizzy Caplan, Caitlin FitzGerald. Episodes. EPISODE 1. Pilot. Noted obstetrician Dr. William Masters (Michael Sheen) teams up with divorced mother Virginia Johnson (Lizzy Caplan) to conduct pioneering research that unleashes the sexual revolution. 58 min · Sep 29, 2013 TV-MA. EPISODE 2. Race to Space.

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