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- Season 6 overviewJan 10-May 9, 201816 episodesSeason 6 episodes16. One Ton Family, Part 2 May 9, 2018
- The revelation of a past tragedy explains the Perrios' resistance to recovery.
- 15. One Ton Family, Part 1 May 2, 2018
- The Perrio siblings travel to Houston in a last-chance journey to lose weight.
- 14. Jennifer & Marissa's Story Apr 11, 2018
- Jennifer and her daughter Marissa are stuck in an unhealthy co-dependent relationship.
- 13. Schenee's Story Apr 4, 2018
- Schenee hopes weight loss surgery will be able to fix her fertility issues as well as her marriage.
- 12. Sarah's Story Mar 28, 2018
- After a difficult childhood, Sarah is fighting for her life at only 24 years old.
- 11. Renee's Story Mar 21, 2018
- Former plus-size model Renee's weight swells to 600 pounds and her health crumbles.
- 10. Benji & David's Story Mar 14, 2018
- Benji hopes to be able to support both himself and his brother on their weight loss journey.
- 9. Tamy Lyn's Story Mar 7, 2018
- Tamy's eating addiction has caused her weight to balloon to over 500 pounds.
- 8. Robert's Story Feb 28, 2018
- Robert turns to Dr. Nowzaradan in a desperate attempt to save his life.
- 7. Lisa's Story Feb 21, 2018
- Lisa's struggle with her weight begins as a child and worsens after witnessing her brother's murder.
- 6. James B.'s Story Feb 14, 2018
- James realizes he must take a new path to save his health and his family relationships.
- 5. Karina's Story Feb 7, 2018
- Karina's weight places a burden on her parents and drives a wedge between her and her sister.
- 4. Liz's Story Jan 31, 2018
- Liz, completely bed-bound, has severe lymphedema that makes it impossible to walk.
- 3. Alicia's Story Jan 24, 2018
- Alicia fears her food addiction will kill her before she can marry or see her nieces grow up.
- 2. Janine's Story Jan 17, 2018
- A woman whose extreme obesity has left her nearly immobile faces physical and emotional pain.
- 1. Rena & Lee's Story Jan 10, 2018
- Lee and Rena battle health and anger issues while taking a desperate attempt to save their lives.