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21 hours ago · Researchers at the University of Toronto have found a way to better control the preclinical generation of key neurons depleted in Parkinson’s disease, pointing toward a new approach for a disease with no cure and few effective treatments.
21 hours ago · Background Adult neurogenesis occurs in the subventricular zone (SVZ) and the subgranular zone of the dentate gyrus in the hippocampus. The neuronal stem cells in these two neurogenic niches respond differently to various physiological and pathological stimuli. Recently, we have found that the decrement of carboxypeptidase E (CPE) with aging impairs the maturation of brain-derived neurotrophic ...
1 day ago · It is often easier to see the next step in a well-studied puzzle than to see an entirely new puzzle, much like seeing the negative space in art. As such, most of the work on adult neurogenesis focuses on the function and regulation of newborn neurons, and substantially less is known about the migration of new neurons in the mature brain.
21 hours ago · We determined that meningeal-derived RA controls neurogenesis by suppressing progenitor self-renewal pathways Notch signaling and the transcription factor Sox2. We show that RARα binds in the Sox2ot promoter, a long non-coding RNA that regulates Sox2 expression, and RA promotes Sox2ot expression in neocortical progenitors.
21 hours ago · In brain regions featuring ongoing plasticity, the task of quickly encoding new information without overwriting old memories presents a significant challenge. In the rodent olfactory bulb, which is renowned for substantial structural plasticity driven by adult neurogenesis and persistent turnover of dendritic spines, we show that such plasticity is vital to overcoming this flexibility ...
2 days ago · The existence of neural stem cells (NSCs) in the adult mammalian nervous system, although small in number and restricted to the sub-ventricular zone of the lateral ventricles, the dentate gyrus of the hippocampus, and the olfactory epithelium, is a gift of evolution for the adaptive brain function which requires persistent plastic changes of these regions. It is known that most adult NSCs are ...
2 days ago · Neurogenesis in the adult human hippocampus is still debated [115, 116] and many questions related to its function and regulation remain unanswered . It is not possible to measure the effects of ...
