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  1. Santa Ana is a city in and the county seat of Orange County, California, United States. Located in the Greater Los Angeles region of Southern California, the city's population was 310,227 at the 2020 census, making Santa Ana the second most populous city in Orange County, the 13th-most populous city in California, and the 64th densest large ...

  2. Coordinates: 33°44′27″N 117°52′53″W. Santa Ana is a city in California. It is the county seat and has the second most people of any city in Orange County. It is the 53rd biggest city in the United States. In 2020, 310,227 people lived in Santa Ana, [5] The city was founded in 1869.

  3. Apr 26, 2024 · Santa Ana, city, seat (1889) of Orange county, southern California, U.S. It lies at the base of the Santa Ana Mountains, on the Santa Ana River. It was explored by the Spaniard Gaspar de Portolá in 1769, and Juan Pablo Grijalva was subsequently (1801) given a land grant for the area, which he named.

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