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- Season 46 overviewOct 3, 2020-May 22, 202120 episodesSeason 46 episodes20. Anya Taylor-Joy; Lil Nas X May 22, 2021
- Host Anya Taylor-Joy; Lil Nas X performs.
- 19. Keegan-Michael Key; Olivia Rodrigo May 15, 2021
- Host Keegan-Michael Key; Olivia Rodrigo performs.
- 18. Elon Musk; Miley Cyrus May 8, 2021
- Host Elon Musk; Miley Cyrus performs.
- 17. Carey Mulligan; Kid Cudi Apr 10, 2021
- Host Carey Mulligan; Kid Cudi performs.
- 16. Daniel Kaluuya; St. Vincent Apr 3, 2021
- Host Daniel Kaluuya; St. Vincent performs.
- 15. Maya Rudolph; Jack Harlow Mar 27, 2021
- Host Maya Rudolph; Jack Harlow performs.
- 14. Nick Jonas Feb 27, 2021
- Nick Jonas hosts and performs.
- 13. Regé-Jean Page; Bad Bunny Feb 20, 2021
- Host Regé-Jean Page; Bad Bunny performs.
- 12. Regina King; Nathaniel Rateliff Feb 13, 2021
- Host Regina King; Nathaniel Rateliff performs.
- 11. Dan Levy; Phoebe Bridgers Feb 6, 2021
- Host Dan Levy; Phoebe Bridgers performs.
- 10. John Krasinski; Machine Gun Kelly Jan 30, 2021
- Host John Krasinski; Machine Gun Kelly performs.
- 9. Kristen Wiig; Dua Lipa Dec 19, 2020
- Host Kristen Wiig; Dua Lipa performs.
- Host Timothée Chalamet; Bruce Springsteen & the E Street Band performs.
- 7. Jason Bateman; Morgan Wallen Dec 5, 2020
- Host Jason Bateman; Morgan Wallen performs.
- 6. Dave Chappelle; Foo Fighters Nov 7, 2020
- Host Dave Chappelle; the Foo Fighters perform.
- 5. John Mulaney; The Strokes Oct 31, 2020
- Host John Mulaney; The Strokes perform.
- 4. Adele; H.E.R. Oct 24, 2020
- Host Adele; H.E.R. performs.
- 3. Issa Rae; Justin Bieber Oct 17, 2020
- Host Issa Rae; Justin Bieber performs.
- 2. Bill Burr; Jack White Oct 10, 2020
- Host Bill Burr; Jack White performs.
- 1. Chris Rock; Megan Thee Stallion Oct 3, 2020
- Host Chris Rock; Megan Thee Stallion performs.