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Simparica Trio is a monthly chewable that protects your dog against heartworm disease, ticks, fleas, and roundworms and hookworms. It is FDA-approved and starts working fast to kill ticks and fleas, and prevent infections that may cause Lyme disease.
Simparica Trio is a monthly chewable that combines sarolaner, moxidectin, and pyrantel to prevent heartworm disease, ticks, fleas, and roundworms and hookworms in dogs. It is FDA-approved to kill deer ticks that may transmit Lyme disease and has a liver-flavored taste that dogs love.
Simparica Trio is a monthly chewable tablet that protects dogs against heartworm disease, ticks, fleas, roundworms and hookworms. Shop by dog weight and get free shipping and eGift card with first order.
- Description
- Simparica Trio Indications
- Simparica Trio Dosage and Administration
- Warnings
- Precautions
- Adverse Reactions
- Contact Information
- Clinical Pharmacology
- Mode of Action
- Heartworm Prevention
SIMPARICA TRIO (sarolaner, moxidectin, and pyrantel chewable tablets) is a flavored, chewable tablet for administration to dogs 8 weeks of age and older. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 µg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Sarolaner is a mem...
SIMPARICA TRIO is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections. SIMPARICA TRIO kills adu...
SIMPARICA TRIO is given orally once a month, at the recommended minimum dose of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 µg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Dosage Schedule SIMPARICA TRIO can be offered to the dog with or without food. Care should be taken to ensure that the dog consumes the complete dos...
Not for use in humans. Keep this and all drugs out of reach of children. Keep SIMPARICA TRIO in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose.
Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a histor...
In a field safety and effectiveness study, SIMPARICA TRIO was administered to dogs for the prevention of heartworm disease. The study included a total of 410 dogs treated once monthly for 11 treatments (272 treated with SIMPARICA TRIO and 138 treated with an active control). Over the 330-day study period, all observations of potential adverse react...
For a copy of the Safety Data Sheet or to report adverse reactions, call Zoetis Inc. at 1-888-963-8471. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or www.fda.gov/reportanimalae.
Following oral administration of SIMPARICA TRIO in Beagle dogs (13 to 15 months of age at the time of initial dosing), sarolaner and moxidectin were rapidly and well-absorbed. Following a single oral dose of SIMPARICA TRIO (sarolaner dose of 1.2 mg/kg), the sarolaner mean maximum plasma concentration (Cmax) was 523 ng/mL with a mean time to maximum...
SIMPARICA TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor, and works at the neuromuscular junction in...
In two well-controlled laboratory studies, a single oral dose of SIMPARICA TRIO was 100% effective in preventing the development of adult D. immitisin dogs inoculated with infective larvae 30 days before treatment. In a well-controlled US field study consisting of 246 dogs administered SIMPARICA TRIO and 119 administered an active control, no dogs ...
Simparica Trio Chewable Tablets for Dogs - 44.1-88 lbs, Green Box at PetSmart. Shop all pharmacy flea & tick online.
Simparica Trio is a monthly chewable that prevents heartworm disease, kills fleas and ticks, and treats and controls roundworms and hookworms in dogs. Learn about its benefits, ingredients, dosage, efficacy, and FAQs on Chewy.com.
Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. Simparica TRIO requires a prescription from your veterinarian.
