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Tissue-type plasminogen activator, short name tPA, is a protein that facilitates the breakdown of blood clots. It acts as an enzyme to convert plasminogen into its active form plasmin, the major enzyme responsible for clot breakdown. It is a serine protease ( EC 3.4.21.68) found on endothelial cells lining the blood vessels.
- PLAT, T-PA, TPA, plasminogen activator, tissue type
Feb 20, 2023 · Tissue plasminogen activator (tPA) is classified as a serine protease (enzymes that cleave peptide bonds in proteins). It is thus one of the essential components of the dissolution of blood clots. Its primary function includes catalyzing the conversion of plasminogen to plasmin, the primary enzyme involved in dissolving blood clots. Recombinant ...
- Talha N. Jilani, Abdul H. Siddiqui
- 2023/02/20
- 2019
Oct 6, 2023 · Tissue plasminogen activator (tPA) is a drug given through a vein to help break up a blood clot so that blood flow can return to normal. It is used for the emergency treatment of ischemic stroke, which occurs when a blood clot interrupts blood flow to a region of the brain. The timely administration of tPA can save lives.
A stroke occurs when the blood supply to brain tissue is blocked by a blood clot (ischemic stroke), or when a blood vessel in the brain ruptures (hemorrhagic stroke), causing brain cells to die and leading to functional impairments.
Mar 7, 2013 · Endovascular therapy is increasingly used after the administration of intravenous tissue plasminogen activator (t-PA) for patients with moderate-to-severe acute ischemic stroke, but whether a...
- Joseph P Broderick, Yuko Y Palesch, Andrew M Demchuk, Sharon D Yeatts, Pooja Khatri, Michael D Hill,...
- 2013
Mar 28, 2023 · Tissue plasminogen activator (tPA) is a medication that doctors administer following a stroke caused by a blood clot. It breaks up the blood clot to allow blood flow to return to the brain....
Dec 6, 2023 · What Is TPA and Why Is It Used for Strokes? Tissue plasminogen activator is a powerful agent that dissolves blood clots. It is injected by intravenous administration (IV) for emergency stroke treatment. A stroke is caused by an interruption in blood flow either due to a blood clot ( ischemic stroke) or a bleed ( hemorrhagic stroke) in the brain.
