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Dr. Samuel Mudd (Warner Baxter) is arrested for being an accomplice to the assassination of Abraham Lincoln (Frank McGlynn Sr.) when he unknowingly aids an injured John Wilkes Booth (Francis McDonald) following the shooting at Ford's Theater. He's sentenced to life in prison and sent to a treacherous penal colony on a remote island in the Dry Tortugas. But when yellow fever breaks out on the island and strikes the prison's doctor, Mudd's medical training becomes invaluable. Wikipedia