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Drug doses are calculated against the LD50 or "Lethal Dose 50%" meaning that dose has a 50% chance to kill the subject. The unit of measure is mg/kg. So lets say something has an LD50 of 100mg/kg. That means a 5g dose has a 50% chance to kill a 50 kg person and a 10g dose to kill a 100 kg person. "Enough poison to kill a herd of elephants" is ...
5 days ago · Radioactivity is the release of ionizing radiation that occurs when the nucleus of a radioactive atom decays. Activity refers to the frequency of radioactive decay (disintegrations per unit time) produced by a given amount of radioactive material. The ionizing radiation released can be in the form of alpha particles, beta particles, or gamma rays.
8 hours ago · The dose–response relationship in gene expression lays a solid foundation for the development of biological markers of low-dose radiation, in line with the findings of Yin et al. and Lee et al ...
1 day ago · The LD 50 in mice has been given as 6.9 mg/kg by intravenous administration, 17.5 mg/kg intraperitoneally, 27.8 mg/kg by oral administration. The LD 50 in humans is unknown. In June 2023, overdose deaths in the U.S. and Canada again reached record numbers.
- C₂₂H₂₈N₂O
- Actiq, Duragesic, Sublimaze, others
- AU: C
3 days ago · Its oral median lethal dose (LD 50) is more than 1,000 mg/kg in mice, rats, and rabbits. There is no specific antidote for overdose of spironolactone. Treatment may consist of induction of vomiting or stomach evacuation by gastric lavage.
- C₂₄H₃₂O₄S
- Aldactone, others
- AU: B3
5 days ago · Effects of Alcohol on BAC. The impact of alcohol on BAC varies depending on several factors, including the number of drinks consumed, the rate of consumption, body weight, metabolism, and individual tolerance. On average, in a person of average build, consuming one standard drink will raise the BAC by approximately 0.01 to 0.03% in an hour.
5 days ago · The 7-day LC 50 found in this study, 19.7 ng/ml, is therefore well within the highest reported venous C max recorded after high oral dose, and the lowest plasma C max achieved from a relatively standard mean 165 μg/kg oral dose, indicating the feasibility of ivermectin as a mosquitocidal in An. coluzzii when dosed clinically.
