- The findings suggest that maternal platelet parameters (MPV, PCT and IPF) can be utilized as evidence of early predictors of development of neonatal sepsis and respiratory distress and may be considered as a predictive markers for adverse neonatal outcome.
People also ask
Which is factors predict hospital-acquired late-onset sepsis?
Which is the most common site of sepsis?
What is early goal directed therapy for sepsis?
What are the signs and symptoms of sepsis?
Jun 09, 2021 · Early-onset sepsis is associated with acquisition of microorganisms from the mother. Infection can occur via hematogenous, transplacental spread from an infected mother or, more commonly, via...
May 19, 2021 · Whereas early-onset neonatal sepsis is usually due to microorganisms that are acquired from the mother antepartum or intrapartum, the pathogens causing late-onset sepsis (LOS) are generally...
May 18, 2021 · The neonatal period refers to the first 28 days of life, which are the most critical for a child’s survival. 1, 2 Globally, 2.4 million children died in the first month of life in 2019. Among the approximated 6700 per day neonatal deaths, about 33% die within the first day of birth, close to 75% die within the first week of life. 1 , 2
Jun 09, 2021 · Sepsis is an overwhelming and life-threatening response to bacteria in bloodstream and a major cause of neonatal morbidity and mortality. Understanding the etiology and potential risk factors for neonatal sepsis is urgently required, particularly in low-income countries where burden of infection is high and its epidemiology is poorly understood.
Jun 07, 2021 · In common clinical usage, neonatal sepsis refers to a bacterial blood stream infection in the first month of life, such as meningitis, pneumonia, pyelonephritis, or gastroenteritis, but neonatal sepsis also may be due to infection with fungi, viruses, or parasites.
- Case Presentations
- Critical Appraisal of The Literature
- Risk Management Pitfalls to Avoid in The Critically Ill Neonate
The ill neonate is a frightening entity for most emergency clinicians. Neonates are a rare entity at many nonpediatric emergency departments (EDs), and when they are brought in, it is frequently for minor complaints.2 When critically ill infants do present, appropriate newborn resuscitation equipment and consultations are often unavailable.3,4 Even when a general pediatric consultation is readily available, the experience with ill children may be limited. One study of academic pediatric training programs indicated that only 36% of graduating residents had led a pediatric resuscitation, and a handful had no pediatric advanced life support (PALS) training.5It is easy to understand why the resuscitation of a neonate can be an intimidating and lonely experience for an emergency clinician. This issue of Pediatric Emergency Medicine Practice will discuss recognition of the causes as well as general and disease-specific means of stabilizing the critically ill neonatal patient. There are ma...
A 5-day-old boy is brought into the emergency department for poor feeding and lethargy. The patient is the full-term product of a vaginal delivery to a healthy mother who received routine prenatal care. He had been eating well—2 oz of formula every 2 hours—until today, when he began sucking poorly and taking less than half an ounce with each feeding. He has been afebrile, and the review of his systems is otherwise negative. On examination, the baby is notably difficult to arouse. He appears slightly jaundiced and mottled, which the mother believes are new findings. His temperature is low at 35.5ºC (95.9ºF), his heart rate is 190 beats per minute, his respiratory rate is 50 breaths per minute, and his blood pressure reading is 66/38 mm Hg. His anterior fontanel is open and flat, his lungs are clear, the cardiac examination reveals significant tachycardia, the liver is palpable 1 cm below the costal margin, results of the abdominal examination are unremarkable, and the capillary refil...
Neonatal mortality information was derived from the National Vital Statistic System maintained by the Centers for Disease Control and Prevention. This is a national reporting database. Small prospective studies on the incidence and test characteristics of neonatal sepsis were also available.
Diagnosis, Treatment, And Outcome Data
Each of the diseases discussed in this article is an uncommon entity, and the diagnosis and treatment is generally based on extrapolation from pathophysiology, expert opinion, and small retrospective data sets. A large prospective study was available on treatment of IEMs and optimal antibiotic therapy for the infected neonate. A well-researched literature review resulting in national guidelines was available regarding screening for congenital heart disease and treatment of neonatal sepsis. Sm...
PubMed® and Ovid MEDLINE® were searched for literature on neonatal emergencies published from 1950 to the present. Multiple search terms were used because of the variety of conditions discussed. Pertinent abstracts were used for non-English language studies."The child did not appear blue, so I didn't investigate the possibility of a cyanotic cardiac anomaly."Apparent cyanosis requires 5 g/dL of deoxygenated hemoglobin. Early in the neonatal period, mo..."The neonate had some bilious emesis, but the plain radiographs of the abdomen were normal."A surgical cause of bilious emesis in the neonate is found in 30% to 40% of cases. In malrotation specifi..."The mother reported a temperature at home, but the infant had no fever in the ED."Tactile fevers can be difficult to interpret. Nevertheless, one retrospective study indicated that in infants with..."The parents say the child rolled off the bed, which may explain the intracranial hemorrhage."Being responsible for removing an infant from his or her home can be difficult; it is even harder when...
Evidence-based medicine requires a critical appraisal of the literature based upon study methodology and number of subjects. Not all references are equally robust. The findings of a large, prospective, randomized, and blinded trial should carry more weight than a case report. 1. McCollough M, Sharieff GQ. Common complaints in the first 30 days of life. Emerg Med Clin North Am. 2002;20(1):27-48. (Review) 2. Calado CS, Pereira AG, Santos VN, et al. What brings newborns to the emergency department?: a 1-year study. Pediatr Emerg Care. 2009;25(4):244-248. (Retrospective; 540 patients) 3. Athey J, Dean JM, Ball J, et al. Ability of hospitals to care for pediatric emergency patients. Pediatr Emerg Care. 2001;17(3):170-174. (Survey; 101 participants) 4. American College of Emergency Physicians. ACEP policy statement: guidelines for care of children in the emergency department. April 2009. http://www.acep.org/practres.aspx?id=29139. Accessed June 18, 2010. (Policy statement) 5. Hunt EA, Pat...
Jun 07, 2021 · This low association between delivery criteria and risk of early onset sepsis was confirmed in cohort studies and the current national guidelines recommend that infants meeting these criteria be...
Jun 12, 2021 · Charlton JR, Boohaker L, Askenazi D, Brophy PD, D’Angio C, Fuloria M, et al. Incidence and risk factors of early onset neonatal AKI. Clin J Am Soc Nephrol. 2019;14:184–95. Article Google Scholar