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Apr 13, 2024 · Eflornithine/Nifurtimox: Eflornithine/Nifurtimox combination therapy (NECT) treats stage two West African sleeping sickness. Eflornithine is administered intravenously twice a day for seven days, and nifurtimox is given three times a day for 10 days.
Apr 22, 2024 · Researchers have been investigating eflornithine-based combination therapies for West African sleeping sickness. The most effective combination has been eflornithine used in conjunction with nifurtimox, an agent used to treat Chagas disease. Prevention
- The Editors of Encyclopaedia Britannica
Apr 26, 2024 · Nifurtimox has been primarily associated with gastrointestinal side effects, including weight loss up to anorexia; joint and muscle pain; and neuro-psychiatric disorders including agitation, disturbed sleep, and headache.
Apr 14, 2024 · Chagas disease can be cured if the treatment (benznidazole or nifurtimox) is administered in the acute phase of the disease, shortly after the initial infection occurs, or when it is administered to children.
Apr 24, 2024 · nifurtimox is an antiprotozoal and is used to treat chagas disease in children under 18 years old who weigh at least 2.5 kg.
Apr 26, 2024 · Frontiers in pharmacology. 2023. TLDR. This review discusses the state-of-the-art of drug repurposing approaches, including combination therapy with existing drugs, to overcome the formidable challenges associated with treating Chagas disease and identifies candidates that exhibit potential for heightened efficacy and reduced toxicity profiles.
Apr 25, 2024 · The best treatment recommended by doctors for stage II is a combination therapy of oral nifurtimox and intravenous eflornithine, which is called NEER. In 2009, the World Health Organization inducted NEER into the list of essential medicines.
