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    • Sepsis: definition, epidemiology, and diagnosis | The BMJ
      • Systemic illness caused by microbial invasion of normally sterile parts of the body is referred to as “sepsis.” This is a term that specifically serves to differentiate an illness of microbial origin from an identical clinical syndrome that can arise in several non-microbial conditions, of which pancreatitis is the archetype.
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    What is sepsis?

    Is sepsis caused by the microbiome or the immune system?

    What is sepsis and septic shock?

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  2. › wiki › SepsisSepsis - Wikipedia

    3 days ago · Microbial factors. Bacterial virulence factors, such as glycocalyx and various adhesins, allow colonization, immune evasion, and establishment of disease in the host. Sepsis caused by gram-negative bacteria is thought to be largely due to a response by the host to the lipid A component of lipopolysaccharide, also called endotoxin.

    • May be rapid (<3 hours) or prolonged (several days)
    • Immune response triggered by an infection
  3. Jan 08, 2022 · Sepsis is a life-threatening syndrome usually caused by bacterial infection. Sepsis is a response of the body's immune system that results in organ dysfunction or failure. The systemic inflammator ...

  4. Dec 29, 2021 · Sepsis is defined as new onset organ dysfunction caused by a dysregulated or failing host response to infection [ 1 ], with septic shock reflecting a more severe form [ 2 ]. Sepsis is associated with increased risk of short-term morbidity and mortality in intensive care units, as well as long-term sequelae [ 3 ].

  5. Jan 13, 2022 · The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801. Hall JB, et al. Sepsis, severe shock, and septic shock.

  6. Jan 07, 2022 · Critical Appraisal of the Literature. To evaluate clinically relevant articles regarding the diagnosis and early management of sepsis, severe sepsis, and septic shock, a search of the National Library of Medicine PubMed database was performed using the following search terms: sepsis management, septic shock management, and clinical sepsis treatment guidelines, with a date range of 2000 to 2018.

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