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    • Sepsis: definition, epidemiology, and diagnosis | The BMJ
      • Systemic illness caused by microbial invasion of normally sterile parts of the body is referred to as “sepsis.” This is a term that specifically serves to differentiate an illness of microbial origin from an identical clinical syndrome that can arise in several non-microbial conditions, of which pancreatitis is the archetype.
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    What is sepsis?

    Is sepsis caused by the microbiome or the immune system?

    What is sepsis and septic shock?

    How is sepsis diagnosed and treated in the emergency department (ED)?

  2. en.wikipedia.org › wiki › SepsisSepsis - Wikipedia

    3 days ago · Microbial factors. Bacterial virulence factors, such as glycocalyx and various adhesins, allow colonization, immune evasion, and establishment of disease in the host. Sepsis caused by gram-negative bacteria is thought to be largely due to a response by the host to the lipid A component of lipopolysaccharide, also called endotoxin.

    • May be rapid (<3 hours) or prolonged (several days)
    • Immune response triggered by an infection
  3. Jan 08, 2022 · Sepsis is a life-threatening syndrome usually caused by bacterial infection. Sepsis is a response of the body's immune system that results in organ dysfunction or failure. The systemic inflammator ...

  4. Dec 29, 2021 · Sepsis is defined as new onset organ dysfunction caused by a dysregulated or failing host response to infection [ 1 ], with septic shock reflecting a more severe form [ 2 ]. Sepsis is associated with increased risk of short-term morbidity and mortality in intensive care units, as well as long-term sequelae [ 3 ].

  5. Jan 13, 2022 · The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801. Hall JB, et al. Sepsis, severe shock, and septic shock.

  6. Jan 07, 2022 · Critical Appraisal of the Literature. To evaluate clinically relevant articles regarding the diagnosis and early management of sepsis, severe sepsis, and septic shock, a search of the National Library of Medicine PubMed database was performed using the following search terms: sepsis management, septic shock management, and clinical sepsis treatment guidelines, with a date range of 2000 to 2018.

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