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  1. The task force sought to differentiate sepsis from uncomplicated infection and to update definitions of sepsis and septic shock to be consistent with improved understanding of the pathobiology. A definition is the description of an illness concept; thus, a definition of sepsis should describe what sepsis “is.”

  2. Oct 14, 2021 · Sepsis has been defined as the presence of the systemic inflammatory response or SIRS, in the presence of a known or suspected source of infection. Severe sepsis was defined as sepsis with organ system dysfunction and septic shock, a subset of severe sepsis, where hypotension and high lactate levels persist despite adequate fluid resuscitation.

  3. Nov 12, 2019 · Sepsis is one of the most important causes of maternal death in the UK, 3 and there is an 8% risk of mortality across HICs. 4, 5 Morbidity, not insignificant in survivors, has an estimated morbidity/mortality ratio of 50:1. 6 The World Health Organization (WHO) reports the prevalence of puerperal sepsis alone in live births as 4.4% (equating to ...

  4. Aug 11, 2022 · Background The Dutch Working Party on Antibiotic Policy (SWAB) in collaboration with relevant professional societies, has updated their evidence-based guidelines on empiric antibacterial therapy of sepsis in adults. Methods Our multidisciplinary guideline committee generated ten population, intervention, comparison, and outcome (PICO) questions relevant for adult patients with sepsis. For each ...

  5. May 23, 2016 · Sepsis, severe sepsis, and septic shock represent increasingly severe systemic inflammatory responses to infection. Sepsis is common in the aging population, and it disproportionately affects patients with cancer and underlying immunosuppression. In its most severe form, sepsis causes multiple organ dysfunction that can produce a state of chronic critical illness characterized by severe immune ...

  6. May 17, 2010 · JHI Special Issue call for papers: Antimicrobial stewardship. Each November, the Journal of Hospital Infection (JHI) publishes a Special Section on antimicrobial stewardship (AMS), to coincide with WHO World Antimicrobial Awareness Week.

  7. Jul 13, 2016 · This guideline covers the recognition, diagnosis and early management of sepsis for all populations. The guideline committee identified that the key issues to be included were: recognition and early assessment, diagnostic and prognostic value of blood markers for sepsis, initial treatment, escalating care, identifying the source of infection, early monitoring, information and support for ...

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