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Dengue fever is one of the major health problems in India. Interaction with specific receptor(s) at the cell surface is one of the first events in the pathogenesis of Dengue virus. However, relatively little is known about these receptors. Cellular receptors in human monocytes and mouse neural cells are main target for the viral infection.
Dengue fever is a mosquito-borne tropical disease caused by dengue virus. It is frequently asymptomatic; if symptoms appear they typically begin 3 to 14 days after infection. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin itching and skin rash. Recovery generally takes two to seven days.
The most widely-cited hypothesis for the pathogenesis of severe dengue is antibody-dependent enhancement (ADE). Although the exact mechanisms are not clear, AD E is the process in which DENV, complexed with nonneutralizing antibodies, can enter a greater proportion of cells of the mononuclear lineage, thus increasing virus production.
Nov 21, 2022 · Dengue virus (DENV) infection is one of the major public health concerns around the globe, especially in the tropical regions of the world that contribute to 75% percent of dengue cases. While the majority of DENV infections are mild or asymptomatic, approximately 5% of the cases develop a severe form of the disease that is mainly attributed to sequential infection with different DENV ...
Jul 6, 2022 · Although dengue pathogenesis is not completely understood, DENV NS1 is regarded as the “viral toxin” and the key mediator for severe disease. Firstly, NS1 activates the complement cascade leading to exaggerated release of vasoactive anaphylatoxins, which in turn cause aberrant activation of mast cells and histamine release leading to ...
Feb 24, 2023 · Pathogenesis of DENV infection is complex and not fully understood though the spectrum of the pathogen severity of all serotypes ranges from mild DF to severe dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) . The pathogenesis is attributed to a complex interaction of the virus, host genes, and immune responses of the host .
Nov 22, 2021 · The Flaviviral lifecycle starts with the (1) internalization of the virion by attachment and receptor-mediated endocytosis. (2) Under the mildly acidic environment of the endosome, the viral membrane fuses with that of the endosomal membrane, uncoats and the nucleocapsid is released into the cytoplasm.
