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11 hours ago · In addition, the intracellular mean fluorescence intensity (MFI) was 3.75 times that of the commercial DLin-MC3-DMA (Fig. 2d), and the colocalization of siRNA and endosomes/lysosomes was ...
11 hours ago · A sequence alignment with SnapGene shows 57.4% identity in the nucleotide sequence. Furthermore, several secondary structures and domains are located in the same regions within the two proteins . However, the enzymes are expressed in different tissues, and even though the 5-Ppase domain specifically seems to be very similar, there are regions ...
11 hours ago · Previous study has identified that FRMD8 is essential for the control of the stability of inactive rhomboid protein 2 (iRhom2) and a disintegrin metalloprotease 17 (ADAM17) on the plasma membrane. Ablation of FRMD8 triggers the mis-sorting of iRhom2 and ADAM17 to lysosomes, where they are degraded . Consistent with this, loss of FRMD8 results ...
11 hours ago · Autophagy is a highly conserved cellular recycling process which enables eukaryotes to maintain both cellular and overall homeostasis through the catabolic breakdown of intracellular components or the selective degradation of damaged organelles. In recent years, the importance of autophagy in vascular endothelial cells (ECs) has been increasingly recognized, and numerous studies have linked ...
11 hours ago · Meanwhile, FTH can be delivered to lysosomes by target binding to NCOA4 for degradation and release free unstable divalent iron, increasing the possibility of ferroautophagy-induced ferroptosis . In present study, we found expression level of FTH increased significantly after TBI in vivo and in vitro, mainly because of the perspective of iron ...
11 hours ago · Heavy metals cause damage to cellular organelles like mitochondria, lysosomes, nuclei, enzymes, and cell membrane. Heavy metal–induced toxicity causes the generation of reactive oxygen and nitrogen species that cause the formation of free radicals that further leads to the modification of DNA bases and changes in calcium homeostasis [ 59 ].
