Search results
Jul 23, 2019 · Azithromycin did not show any inhibition of both transporters.34 Hirano et al calculated the inhibition constant for clarithromycin and erythromycin against OATP1B1 and found that clarithromycin has a stronger affinity for OATP1B1 than erythromycin (8.25 µM and 11.4 µM respectively) and may cause a significant clinical interaction with ...
Aug 27, 2016 · A meta-analysis which examined the doses of clarithromycin found that when the PAC regimen was used, pooled data from clinical trials showed eradication rates of 79.8% with clarithromycin 250 mg twice daily compared to 89.6% with clarithromycin 500 mg twice daily (Huang and Hunt, 1999).
Sep 4, 1992 · Therapeutic concentrations of clarithromycin have also been found to stimulate protein kinase C activity in polymorphonuclear leukocytes (PMNLs). Thus, in addition to its antimicrobial activity, the drug stimulates cellular host defense mechanisms involving the activation of protein kinase C ( 12 ).
Methods and results: In a detailed literature search, we found 15 women, five men, and one boy meeting our search criteria. Among the 17 adults with reported clarithromycin dose and concurrent QTc interval measurement, we found no statistically significant relationship between clarithromycin dose and QTc interval duration.
May 23, 2015 · In the more recently included trial, fusafungine or fusafungine plus clarithromycin were more effective than no treatment in patients with acute laryngitis at day five, but no significant differences were found at days eight and 28 (Rafalskiy 2012). However, no significant differences were found when adding clarithromycin to fusafungine.
Dec 6, 2022 · Clarithromycin triple therapy consists of a standard dose of PPI, clarithromycin 500 mg, and amoxicillin 1 g, all taken twice a day, or metronidazole 500 mg three times daily . Metronidazole 500 mg three times daily is used as a substitute when the patient is allergic to penicillin, and it is recommended to be given over 14 days [ 5 ].
Aug 8, 2008 · The renal clearance of clarithromycin is, however, relatively independent of the dose size and approximates the normal glomerular filtration rate. The major metabolite found in urine is 14-OH clarithromycin, which accounts for an additional 10% to 15% of the dose with either a 250 mg or a 500 mg tablet administered every 12 hours.
