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Learn About This Rare Condition at the Patient Site. Find More Information About VHL Disease.
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Jun 22, 2022 · von Willebrand disease affects 1% of the U.S. population and is the most common bleeding disorder in the United States. Globally, von Willebrand disease affects an estimated 23 to 110 in 1 million people. The numbers vary because people may have bleeding issues, but aren’t diagnosed with von Willebrand disease.
Apr 16, 2024 · There are three major types of inherited von Willebrand disease (VWD), named 1, 2, and 3: Type 1 is the most common form, affecting approximately three-quarters of people who have inherited VWD. People with this type have low levels of VWF in the blood due either to not making enough von Willebrand factor (VWF) or to having abnormally fast ...
Von Willebrand disease (VWD) is the most common hereditary blood-clotting disorder in humans. An acquired form can sometimes result from other medical conditions. [1] It arises from a deficiency in the quality or quantity of von Willebrand factor (VWF), a multimeric protein that is required for platelet adhesion .
Von Willebrand disease is classified into 3 main types: Type 1: A quantitative deficiency of VWF, which is the most common form and is an autosomal dominant disorder. VWD concentration and activity are both reduced proportionally. Type 2: A qualitative impairment in synthesis and function of VWF that can result from various genetic ...
Type 3: With this rarest type of VWD, people make very small amounts of von Willebrand clotting factor or none at all. Type 3 poses the greatest bleeding risk and often needs ongoing treatment. Von Willebrand Disease Symptoms. Most people with VWD have a milder form. Symptoms may include easy bruising and prolonged nosebleeds or bleeding from ...
Jan 11, 2021 · The American Society of Hematology (ASH), the International Society on Thrombosis and Haemostasis (ISTH), National Hemophilia Foundation (NHF), and World Federation of Hemophilia (WFH) have developed joint clinical practice guidelines on the diagnosis and management of von Willebrand disease (VWD), the world’s most common inherited bleeding disorder.
Dec 1, 2009 · Von Willebrand disease is an inherited condition characterized by deficiency of von Willebrand factor, which is essential in hemostasis. ... The authors of this article are members of the NHLBI ...
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