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- The immune suppressed state can modify the cardinal signs of inflammation, making accurate and rapid diagnosis of infection and sepsis difficult. Empiric antimicrobial agents can be lifesaving in these patients, but managing therapy in an era of progressive antibiotic resistance has become a real issue.
pubmed.ncbi.nlm.nih.gov › 25939918
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May 17, 2016 · The diagnosis of sepsis in critically ill patients is challenging, because it can be complicated by the presence of inflammation as a result of other underlying disease processes and prior use of antibiotics making cultures negative.
Oct 25, 2021 · Similarly, PCT exhibits a lower diagnostic AUROC and sensitivity for predicting bacterial infection in patients with renal impairment (defined by an estimated glomerular filtration rate < 30 mL/min/1.72 m 2) , immunocompromised patients and in patients with autoimmune conditions .
- Chris F. Duncan, Taryn Youngstein, Taryn Youngstein, Marianne D. Kirrane, Marianne D. Kirrane, Dagan...
- 2021
Jul 21, 2020 · A consequence of the need for this permanent immunosuppression is the high risk of opportunistic, community, and hospital-acquired infections, all of which can lead to sepsis. In addition, the detection of serious infections may be more challenging owing to patients' lower ability to mount the clinical symptoms that usually accompany sepsis.
- Randy J McCreery, Diana F Florescu, Andre C Kalil
- 2020
Jul 21, 2020 · Although immunocompromised patients are at high risk of sepsis and septic shock [ 5–8 ], it has been observed that their mortality rate due to sepsis is no greater, and is in some cases less [ 3, 9, 10 ], than the rate seen in nonimmunocompromised patients [ 6, 11–15 ].
- Randy J McCreery, Diana F Florescu, Andre C Kalil
- 2020
Jul 21, 2020 · Topic: sepsis. biological markers. surveillance, medical. antimicrobial stewardship. Issue Section: supplement articles. Sepsis is defined as a dysregulated immune response to infection affecting millions of individuals per year and carries high morbidity and mortality rates even if appropriate care is provided [ 1, 2 ].
- Edward J Septimus
- 2020
Although many patients with sepsis have fever, the clinical manifestation can be subtle, particularly in older patients and those who are immunocompromised. Initial evaluation of patients...
Dec 19, 2023 · The immune response caused by the pathogen is complex, resulting in a dysregulated innate and adaptive immune response that, if not promptly controlled, can lead to excessive inflammation,...
