The prevention and treatment of sepsis in the immunocompromised host present a challenging array of diagnostic and management issues. The neutropenic patient has a primary defect in innate immune responses and is susceptible to conventional and opportunistic pathogens.
- Andre C. Kalil, Steven M. Opal
In 2017, most intensive care units (ICUs) worldwide are admitting a growing population of immunosuppressed patients. The most common causes of pre-ICU immunosuppression are solid organ transplantation, hematopoietic stem cell transplantation, and infection due to human immunodeficiency virus.
- Diana F. Florescu, Uriel Sandkovsky, Andre C. Kalil
Sepsis remains among the most common complications from infectious diseases worldwide. The morbidity and mortality rates associated with sepsis range from 20% to 50%. The advances in care for patients with an immunocompromised status have been remarkable over the last 2 decades, but sepsis continues …
- Randy J McCreery, Diana F Florescu, Andre C Kalil
May 17, 2016 · Summary Points. Early treatment of sepsis is associated with improved outcomes so that rapid diagnosis is important. The diagnosis of sepsis in critically ill patients is challenging, because it can be complicated by the presence of inflammation as a result of other underlying disease processes and prior use of antibiotics making cultures negative.
- Jean Louis Vincent
Severe cases of sepsis often result from a body-wide infection that spreads through the bloodstream. In some cases, bloodstream infection cannot be detected, and doctors use other information such as body temperature and mental status to diagnose sepsis. Sepsis often results from infections to the lungs, stomach, kidneys, or bladder. It’s
The source of infection in the majority of patients is the patient’s endogenous microbiota that is enabled to translocate across mucocutaneous barriers secondary to chemotherapy-induced mucosal injury of the oral cavity and intestinal epithelium and due to indwelling vascular and urinary catheters . The course of mucositis after standard or ...
• Infections in the immunocompromised host: 9More difficult to diagnose 9Infection often more advanced at the time of diagnosis 9Complicated by other medical problems, drug toxicities, etc. 9The intensity of immunosuppression is as important as antimicrobial therapy Summary • Clinicians caring for patients receiving