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What is familial acholuric jaundice?
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Jaundice, also known as icterus, is a yellowish or greenish pigmentation of the skin and sclera due to high bilirubin levels. Jaundice in adults is typically a sign indicating the presence of underlying diseases involving abnormal heme metabolism, liver dysfunction, or biliary-tract obstruction.
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Bilirubin (BR) (from the Latin for "red bile") is a...
- Gilbert's Syndrome
Gilbert syndrome (GS) is a syndrome in which the liver of...
- Kernicterus
Kernicterus is a bilirubin-induced brain dysfunction. The...
- Neonatal Jaundice
Neonatal jaundice is a yellowish discoloration of the white...
- High Bilirubin Levels
Hemolytic jaundice, also known as prehepatic jaundice, is a type of jaundice arising from hemolysis or excessive destruction of red blood cells, when the byproduct bilirubin is not excreted by the hepatic cells quickly enough.
Jan 31, 2012 · Clinically, jaundice becomes apparent when bilirubin levels are ∼40 μmol/l, which is two to three times the normal value, depending on the laboratory’s selected reference range. 1 The incidence of clinically apparent jaundice in primary care has not been described, although experience suggests it is relatively rare.
- Anna Taylor, Sally Stapley, William Hamilton
- 2012
Oct 31, 2011 · Bilirubin, a degradation product of heme, circulates bound to albumin, from which it is extracted in the liver. It is translocated from blood to bile by a multistep process involving hepatocellular uptake, intracellular binding, conjugation with glucuronic acid, and active transport into bile. Hyperbilirubinemias are predominantly unconjugated ...
- Allan W. Wolkoff, Paul D. Berk
- 2011
Abstract. Acholuric jaundice has long been recognized and frequently seen in many conditions with various clinical designations. Most commonly it is ascribed to some disorder of the liver or to anemia, but because no bile appears in the urine little investigation has been made of such jaundice.
acholuric jaundice: [ jawn´dis ] yellowness of skin, sclerae, mucous membranes, and excretions due to hyperbilirubinemia and deposition of bile pigments . It is usually first noticeable in the eyes, although it may come on so gradually that it is not immediately noticed by those in daily contact with the jaundiced person. Called also icterus . ...
Dec 20, 2001 · The term ‘hereditary spherocytosis’ was suggested to replace familial haemolytic icterus or congenital acholuric jaundice by the Third Committee for the Clarification of the Nomenclature of Cells and Diseases of the Blood and Blood-forming Organs (1950), at their meeting in 1948. They reasoned that not all patients with this disorder ...
