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  1. May 28, 2021 · Pathophysiology of acute respiratory distress syndrome. Acute respiratory distress syndrome (ARDS) is a complex syndrome of acute lung injury leading to noncardiogenic pulmonary edema from many causes that is heterogenous in its clinical presentation and associated with a 40% mortality rate. 1 Extensive work since its initial description in 1967 has elucidated biological pathways causing the ...

    • Fig. 1

      Values are those at a fractional inspired O 2 concentration...

    • Table 1

      Comparisons between pathophysiology of COVID-19 lung injury...

  2. May 26, 2021 · In this review, some of the recent advances made in our understanding of the pathophysiology of ARDS based on human studies are summarized. Furthermore, the pathophysiology of lung injury in coronavirus disease 2019 (COVID-19), the disease manifest by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is reviewed. Fig. 1.

    • Pratik Sinha, Lieuwe D. Bos
    • 10.1016/j.ccc.2021.05.005
    • 2021
    • Crit Care Clin. 2021 Oct; 37(4): 795-815.
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  4. Sep 4, 2022 · Acute respiratory distress syndrome (ARDS) is a common clinical syndrome of acute respiratory failure as a result of diffuse lung inflammation and oedema. ARDS can be precipitated by a variety of causes. The pathophysiology of ARDS is complex and involves the activation and dysregulation of multiple overlapping and interacting pathways of injury, inflammation, and coagulation, both in the lung ...

  5. Apr 7, 2020 · Common etiologies include drug overdose, neuromuscular disease, chest wall abnormalities, and severe airway disorders (eg, asthma and chronic obstructive pulmonary disease [COPD]). Respiratory failure may be further classified as either acute or chronic. Although acute respiratory failure is characterized by life-threatening derangements in ...

  6. Acute respiratory distress syndrome (ARDS) is a heterogeneous clinical syndrome that manifests secondary to numerous etiologic insults, and consequently it is associated with a multitude of pathophysiological abnormalities. Despite more than 50 years of experimental studies, translation of these benchside discoveries into effective biological therapies has been elusive. In this review, some of ...

  7. Bach-ofen and Weibel15 differentiated these histopathological changes in ARDS temporally into the following 3 phases: (1) exudative (early) phase characterized by interstitial. Table 2 The Berlin definition for clinical diagnosis of acute respiratory distress syndrome. Variable. Criteria. Timing.

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